{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang G"],"funding":["National Natural Science Foundation of China","National Key Research and Development Program of China"],"pagination":["181"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12918629"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["Antibiotics remain the recommended first-line therapy for eradicating Helicobacter pylori infection. However, the harsh gastric physicochemical environment severely limits drug bioavailability, contributing to treatment failure (~10%), gut dysbiosis, and the emergence of antimicrobial resistance. Inspired by H. pylori adhesins binding to gastric epithelial glycan, we developed a biomimetic nanocomposite drug delivery system (BSNG) composed of genetically engineered adhesin-functionalized silk fibroin nanoparticles (BS-NPs) embedded within a fluid silk fibroin hydrogel (FSF-Gel) for targeted anti-H. pylori therapy. BS-NPs exhibit H. pylori-like adhesion to gastric epithelial cells, enabling prolonged gastric retention of over 72 h. FSF-Gel provides conformal coverage of the gastric mucus la"],"journal":["Journal of nanobiotechnology"],"pubmed_title":["Silk-based biomimetic nanocomposite for precision eradication of Helicobacter pylori and gut microbiome preservation."],"pmcid":["PMC12918629"],"funding_grant_id":["32172798","2022YFD1201600","32030103"],"pubmed_authors":["Huang G","Zhao P","Xia Q","Tian C","Liu Q","Wang F","Wang Y","He Q"],"additional_accession":[]},"is_claimable":false,"name":"Silk-based biomimetic nanocomposite for precision eradication of Helicobacter pylori and gut microbiome preservation.","description":"Antibiotics remain the recommended first-line therapy for eradicating Helicobacter pylori infection. However, the harsh gastric physicochemical environment severely limits drug bioavailability, contributing to treatment failure (~10%), gut dysbiosis, and the emergence of antimicrobial resistance. Inspired by H. pylori adhesins binding to gastric epithelial glycan, we developed a biomimetic nanocomposite drug delivery system (BSNG) composed of genetically engineered adhesin-functionalized silk fibroin nanoparticles (BS-NPs) embedded within a fluid silk fibroin hydrogel (FSF-Gel) for targeted anti-H. pylori therapy. BS-NPs exhibit H. pylori-like adhesion to gastric epithelial cells, enabling prolonged gastric retention of over 72 h. FSF-Gel provides conformal coverage of the gastric mucus la","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T10:06:33.231Z","creation":"2026-07-09T10:48:57.81Z"},"accession":"S-EPMC12918629","cross_references":{"pubmed":["41588522"],"doi":["10.1186/s12951-026-04050-9"]}}