{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Downing BE"],"funding":["Kinship Foundation","U.S. Department of Energy","Simons Foundation","National Science Foundation Graduate Research Fellowship Program","Alfred P. Sloan Foundation","National Institutes of Health","David and Lucile Packard Foundation","NIH HHS","Arnold and Mabel Beckman Foundation"],"pagination":["e0044825"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12918732"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["208(2)"],"pubmed_abstract":["Methanogenic archaea (methanogens) are microorganisms that obligately produce methane as a byproduct of their energy metabolism. While most methanogens grow on CO<sub>2</sub>+H<sub>2</sub>, isolates of the genera <i>Methanosarcina</i> and <i>Methanothrix</i> can use acetate as the sole substrate for methanogenesis. Methanogenic growth on acetate, i.e., acetoclastic methanogenesis, is hypothesized to require two distinct genetic modules: one for the activation of acetate to acetyl-CoA and another for producing a chemiosmotic gradient using electrons derived from ferredoxin. In <i>Methanosarcina</i> spp., the activation of acetate to acetyl-CoA is mediated by acetate kinase (Ack) and phosphotransacetylase (Pta), whereas <i>Methanothrix</i> spp. encode AMP-forming acetyl-CoA synthetases (Acs)"],"journal":["Journal of bacteriology"],"pubmed_title":["Genus-specific remodeling of carbon and energy metabolism facilitates acetoclastic methanogenesis in &lt;i&gt;Methanosarcina&lt;/i&gt; spp. and &lt;i&gt;Methanothrix&lt;/i&gt; spp."],"pmcid":["PMC12918732"],"funding_grant_id":["Packard Fellowship in Science and Engineering","202299857","Beckman Young investigator Award","Searle Scholars Award","Early Career Investigator in Marine Microbial Ecology and Evolution","F32GM150233","S589706","Sloan Research Fellowship"],"pubmed_authors":["Shalvarjian KE","Downing BE","Gupta D","Nayak DD"],"additional_accession":[]},"is_claimable":false,"name":"Genus-specific remodeling of carbon and energy metabolism facilitates acetoclastic methanogenesis in &lt;i&gt;Methanosarcina&lt;/i&gt; spp. and &lt;i&gt;Methanothrix&lt;/i&gt; spp.","description":"Methanogenic archaea (methanogens) are microorganisms that obligately produce methane as a byproduct of their energy metabolism. While most methanogens grow on CO<sub>2</sub>+H<sub>2</sub>, isolates of the genera <i>Methanosarcina</i> and <i>Methanothrix</i> can use acetate as the sole substrate for methanogenesis. Methanogenic growth on acetate, i.e., acetoclastic methanogenesis, is hypothesized to require two distinct genetic modules: one for the activation of acetate to acetyl-CoA and another for producing a chemiosmotic gradient using electrons derived from ferredoxin. In <i>Methanosarcina</i> spp., the activation of acetate to acetyl-CoA is mediated by acetate kinase (Ack) and phosphotransacetylase (Pta), whereas <i>Methanothrix</i> spp. encode AMP-forming acetyl-CoA synthetases (Acs)","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T10:05:15.572Z","creation":"2026-07-09T10:48:41.41Z"},"accession":"S-EPMC12918732","cross_references":{"pubmed":["41568973"],"doi":["10.1128/jb.00448-25"]}}