{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wei W"],"funding":["Ministry of Agriculture and Rural Affairs of the People&apos;s Republic of China","Agriculture Research System of China"],"pagination":["106521"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12919248"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["105(4)"],"pubmed_abstract":["Excessive accumulation of abdominal fat (AF) reduces feed efficiency and carcass yield, posing a significant challenge to the poultry industry. However, the molecular network underlying age-dependent AF development remains unclear, despite some recent progress. In this study, we quantified the abdominal adipocyte area and sequenced 20 AF transcriptomes from eight 9-week-old (9 W) and twelve 20-week-old (20 W) Wannan chickens. The abdominal adipocyte area increased significantly at 20 W compared with 9 W (p < 0.001). Differentially expressed gene analysis between the two age groups revealed 235 up-regulated and 206 down-regulated genes in the 20 W. Enrichment analysis revealed the cytokine-cytokine receptor interaction, cell adhesion molecules, TGF-beta signaling pathway, and biological pro"],"journal":["Poultry science"],"pubmed_title":["Transcriptomic analysis identifies hub genes involved in age-dependent abdominal fat development in chickens."],"pmcid":["PMC12919248"],"funding_grant_id":["CARS-41"],"pubmed_authors":["Li C","Chen Z","Guo X","Huang N","Jiang R","Wei W","Wang H","Jiao J","Zhang C"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic analysis identifies hub genes involved in age-dependent abdominal fat development in chickens.","description":"Excessive accumulation of abdominal fat (AF) reduces feed efficiency and carcass yield, posing a significant challenge to the poultry industry. However, the molecular network underlying age-dependent AF development remains unclear, despite some recent progress. In this study, we quantified the abdominal adipocyte area and sequenced 20 AF transcriptomes from eight 9-week-old (9 W) and twelve 20-week-old (20 W) Wannan chickens. The abdominal adipocyte area increased significantly at 20 W compared with 9 W (p < 0.001). Differentially expressed gene analysis between the two age groups revealed 235 up-regulated and 206 down-regulated genes in the 20 W. Enrichment analysis revealed the cytokine-cytokine receptor interaction, cell adhesion molecules, TGF-beta signaling pathway, and biological pro","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T07:51:36.905Z","creation":"2026-07-09T10:46:06.594Z"},"accession":"S-EPMC12919248","cross_references":{"pubmed":["41643434"],"doi":["10.1016/j.psj.2026.106521"]}}