{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29(2)"],"submitter":["Morgan EW"],"pubmed_abstract":["Diet-phytochemical derived activation, host and microbial tryptophan metabolism represent the dominant route to endogenously mediated stimulation of physiological Ah receptor (AHR) activity. Whether host tryptophan metabolism provides a phytochemical independent circadian AHR tone has not been established. Using mice maintained on a nocturnally restricted feeding schedule with a nutritionally defined diet, we utilized quantitative gene/protein expression analyses in conjunction with targeted metabolomics to examine the temporal relationship between host tryptophan metabolism and circadian AHR activity. Time-resolved, targeted LCMS metabolomic, gene, and protein expression analyses reveal circadian cycling of hepatic tryptophan metabolizing enzymes (TDO2, TAT, GOT1, GOT2, KAT1, KAT2, and IL"],"journal":["iScience"],"pagination":["114680"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12919285"],"repository":["biostudies-literature"],"pubmed_title":["Circadian tryptophan metabolism contributes to systemic aryl hydrocarbon receptor activity."],"pmcid":["PMC12919285"],"pubmed_authors":["Patterson AD","Perdew GH","Morgan EW","Murray IA","Coslo DM"],"additional_accession":[]},"is_claimable":false,"name":"Circadian tryptophan metabolism contributes to systemic aryl hydrocarbon receptor activity.","description":"Diet-phytochemical derived activation, host and microbial tryptophan metabolism represent the dominant route to endogenously mediated stimulation of physiological Ah receptor (AHR) activity. Whether host tryptophan metabolism provides a phytochemical independent circadian AHR tone has not been established. Using mice maintained on a nocturnally restricted feeding schedule with a nutritionally defined diet, we utilized quantitative gene/protein expression analyses in conjunction with targeted metabolomics to examine the temporal relationship between host tryptophan metabolism and circadian AHR activity. Time-resolved, targeted LCMS metabolomic, gene, and protein expression analyses reveal circadian cycling of hepatic tryptophan metabolizing enzymes (TDO2, TAT, GOT1, GOT2, KAT1, KAT2, and IL","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T17:55:36.679Z","creation":"2026-07-09T11:10:14.971Z"},"accession":"S-EPMC12919285","cross_references":{"pubmed":["41727182"],"doi":["10.1016/j.isci.2026.114680"]}}