biostudies-literatureUnknown10(2)Woll F<h4>Background</h4>Pericardial cysts are a rare form of congenital mediastinal cystic lesion. They are usually asymptomatic and are often discovered incidentally, although some patients may present with a variety of different symptoms. The presence of small, asymptomatic pericardial cysts does not need treatment; however, large and/or symptomatic cysts may require surgical intervention.<h4>Case summary</h4>We report a case of a 42-year-old man with a 7-year history of dysphagia and non-specific thoracic complaints. Multiple gastroenterological examinations and proton pump inhibitor therapies did not find the cause or led to improvement of the symptoms. Finally, a giant pericardial cyst with compression of the oesophagus as well as a lung atelectasis was identified as the cause of the patieEuropean heart journal. Case reportsytag039https://www.ebi.ac.uk/biostudies/studies/S-EPMC12919348biostudies-literatureA giant pericardial cyst as rare cause of reflux and chest discomfort: a case report.PMC12919348Maeder MTEhl NFChenevard RWoll FfalseA giant pericardial cyst as rare cause of reflux and chest discomfort: a case report.<h4>Background</h4>Pericardial cysts are a rare form of congenital mediastinal cystic lesion. They are usually asymptomatic and are often discovered incidentally, although some patients may present with a variety of different symptoms. The presence of small, asymptomatic pericardial cysts does not need treatment; however, large and/or symptomatic cysts may require surgical intervention.<h4>Case summary</h4>We report a case of a 42-year-old man with a 7-year history of dysphagia and non-specific thoracic complaints. Multiple gastroenterological examinations and proton pump inhibitor therapies did not find the cause or led to improvement of the symptoms. Finally, a giant pericardial cyst with compression of the oesophagus as well as a lung atelectasis was identified as the cause of the patie2026-01-01T00:00:00Z2026 Feb2026-07-09T12:17:52.26Z2026-07-09T11:15:24.355ZS-EPMC129193484172823410.1093/ehjcr/ytag039