biostudies-literatureUnknown78(2)Cheung CK<h4>Objective</h4>Lupus low disease activity state (LLDAS) is a validated treatment target in systemic lupus erythematosus (SLE), but limited studies have explored the role of LLDAS in lupus nephritis (LN). This study aims to investigate the frequency and predictors of LLDAS attainment and its benefit on LN relapse and renal function preservation in patients with LN.<h4>Methods</h4>Patients with LN during 2010 to 2020 in Queen Mary Hospital and Pamela Youde Nethersole Eastern Hospital were included in the discovery cohort and validation cohort, respectively. Complete renal response (CRR), partial renal response (PRR), LLDAS, and Definition Of Remission In SLE (DORIS) remission were assessed at 12 months. Regression analysis was performed to identify risk factors of LN relapse. Receiver opeArthritis care & research227-236https://www.ebi.ac.uk/biostudies/studies/S-EPMC12919694biostudies-literatureReduction in Renal Relapse and Preservation of Long-Term Kidney Function After Lupus Low Disease Activity in Patients With Lupus Nephritis.PMC12919694Yap DYHChan SCWLi PHCheung CKLee KLLau CSTang IYKfalseReduction in Renal Relapse and Preservation of Long-Term Kidney Function After Lupus Low Disease Activity in Patients With Lupus Nephritis.<h4>Objective</h4>Lupus low disease activity state (LLDAS) is a validated treatment target in systemic lupus erythematosus (SLE), but limited studies have explored the role of LLDAS in lupus nephritis (LN). This study aims to investigate the frequency and predictors of LLDAS attainment and its benefit on LN relapse and renal function preservation in patients with LN.<h4>Methods</h4>Patients with LN during 2010 to 2020 in Queen Mary Hospital and Pamela Youde Nethersole Eastern Hospital were included in the discovery cohort and validation cohort, respectively. Complete renal response (CRR), partial renal response (PRR), LLDAS, and Definition Of Remission In SLE (DORIS) remission were assessed at 12 months. Regression analysis was performed to identify risk factors of LN relapse. Receiver ope2026-01-01T00:00:00Z2026 Feb2026-07-16T09:21:10.502Z2026-07-09T10:47:09.231ZS-EPMC129196944068584610.1002/acr.25611