{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(2)"],"submitter":["Doering JE"],"funding":["Moderna"],"pubmed_abstract":["Breast milk confers infants with immunity to a multitude of pathogens reflective of prior maternal infections and vaccinations. However, in outbreak situations where infants may be vulnerable to lethal infections due to gaps in the maternal immune repertoire, a case can be made for supplementing breast milk with one or more pathogen-specific monoclonal antibodies (mAbs) with known prophylactic or therapeutic activity. As oral delivery of recombinant IgG and IgA mAbs to infants has proven challenging, we investigated the use of mRNA-lipid nanoparticle (LNP) technology to stimulate pathogen-specific mAbs in milk. mRNA encoding the Vibrio cholerae O1 specific mAb, ZAC-3, as a human IgG1 or dimeric IgA2, was encapsulated in lipid nanoparticles (LNP) and administered parenterally to lactating a"],"journal":["PLoS neglected tropical diseases"],"pagination":["e0013518"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12919922"],"repository":["biostudies-literature"],"pubmed_title":["Maternal expression and breast milk transfer of an mRNA- encoded monoclonal antibody in a murine model of cholera."],"pmcid":["PMC12919922"],"pubmed_authors":["Plante O","Doering JE","Carfi A","Adewunmi Y","Mantis NJ","Deal CE"],"additional_accession":[]},"is_claimable":false,"name":"Maternal expression and breast milk transfer of an mRNA- encoded monoclonal antibody in a murine model of cholera.","description":"Breast milk confers infants with immunity to a multitude of pathogens reflective of prior maternal infections and vaccinations. However, in outbreak situations where infants may be vulnerable to lethal infections due to gaps in the maternal immune repertoire, a case can be made for supplementing breast milk with one or more pathogen-specific monoclonal antibodies (mAbs) with known prophylactic or therapeutic activity. As oral delivery of recombinant IgG and IgA mAbs to infants has proven challenging, we investigated the use of mRNA-lipid nanoparticle (LNP) technology to stimulate pathogen-specific mAbs in milk. mRNA encoding the Vibrio cholerae O1 specific mAb, ZAC-3, as a human IgG1 or dimeric IgA2, was encapsulated in lipid nanoparticles (LNP) and administered parenterally to lactating a","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T09:24:24.593Z","creation":"2026-07-09T10:46:47.207Z"},"accession":"S-EPMC12919922","cross_references":{"pubmed":["41662412"],"doi":["10.1371/journal.pntd.0013518"]}}