{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alcala K"],"funding":["Umeå Universitet","World Cancer Research Fund","Cancer Research UK","Bengt Ihres Foundation","Svenska Läkaresällskapet","Medical Research Council","National Institute for Health Research (NIHR)","National Institute for Health and Care Research","Svensk-Franska Stiftelsen","NIHR Bristol Biomedical Research Centre"],"pagination":["e1004906"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12919923"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(2)"],"pubmed_abstract":["<h4>Background</h4>Excess body adiposity is an established cause of renal cancer, but underlying molecular pathways mediating this relationship remain unclear. This study aimed to systematically evaluate a panel of obesity-related risk factors as potential mediators in renal cancer etiology.<h4>Methods and findings</h4>We used two complementary approaches to evaluate obesity-related risk factors in renal cancer etiology: (i) direct risk factor assessment in longitudinal cohorts and (ii) genetically proxied risk factors through two-sample mendelian randomization (MR). Direct risk-factor association-analyses (i.e., cohort analyses) were based on the UK Biobank cohort study (472,337 cohort participants, including 1,382 incident renal cancer cases diagnosed during 5,586,414 person years of fol"],"journal":["PLoS medicine"],"pubmed_title":["Systematic assessment of obesity-related risk factors in renal cancer etiology: A longitudinal risk and mendelian randomization analysis."],"pmcid":["PMC12919923"],"funding_grant_id":["F0025_230413","NIHR202411","IIG_2019_1995","FS 2.1.6-59-23","C18281/A29019","MC_UU_00032/1","SLS-960379","BRC-1215-20011","PRCPGM-May25/100001"],"pubmed_authors":["Brennan P","Franklin O","Pollak M","Alcala K","Langdon R","Jacobson S","Smith GD","Dimou N","Mariosa D","Martin RM","Johansson M","Gunter MJ","Coscia-Requena C"],"additional_accession":[]},"is_claimable":false,"name":"Systematic assessment of obesity-related risk factors in renal cancer etiology: A longitudinal risk and mendelian randomization analysis.","description":"<h4>Background</h4>Excess body adiposity is an established cause of renal cancer, but underlying molecular pathways mediating this relationship remain unclear. This study aimed to systematically evaluate a panel of obesity-related risk factors as potential mediators in renal cancer etiology.<h4>Methods and findings</h4>We used two complementary approaches to evaluate obesity-related risk factors in renal cancer etiology: (i) direct risk factor assessment in longitudinal cohorts and (ii) genetically proxied risk factors through two-sample mendelian randomization (MR). Direct risk-factor association-analyses (i.e., cohort analyses) were based on the UK Biobank cohort study (472,337 cohort participants, including 1,382 incident renal cancer cases diagnosed during 5,586,414 person years of fol","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T10:01:36.958Z","creation":"2026-07-09T10:48:07.929Z"},"accession":"S-EPMC12919923","cross_references":{"pubmed":["41666231"],"doi":["10.1371/journal.pmed.1004906"]}}