{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(2)"],"submitter":["Reimann GR"],"pubmed_abstract":["Cellular membrane trafficking, including endocytosis and exocytosis, is a complex process coordinated by trafficking-associated proteins, cargo molecules, the cytoskeleton, and membrane lipids. The NIMA-related kinases NEKL-2 (human NEK8/9) and NEKL-3 (human NEK6/7) are conserved regulators of membrane trafficking in Caenorhabditis elegans that are required for the completion of molting. Using a genetic approach, we isolated reduction-of-function mutations in piki-1 that suppress nekl-associated molting defects. piki-1 encodes the sole predicted C. elegans Class II PI 3-kinase (PI3K), a relatively understudied class of lipid modifiers that contribute to the production of PI 3-phosphate (PI(3)P) and PI 3,4-bisphosphate (PI(3,4)P2). Using genetically encoded lipid sensors, we found that PIKI"],"journal":["PLoS genetics"],"pagination":["e1011740"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12919929"],"repository":["biostudies-literature"],"pubmed_title":["PIKI-1, a class II PI 3-kinase, functions in endocytic trafficking."],"pmcid":["PMC12919929"],"pubmed_authors":["Fay DS","Conquest S","Grant BD","Reimann GR","Edeen PT"],"additional_accession":[]},"is_claimable":false,"name":"PIKI-1, a class II PI 3-kinase, functions in endocytic trafficking.","description":"Cellular membrane trafficking, including endocytosis and exocytosis, is a complex process coordinated by trafficking-associated proteins, cargo molecules, the cytoskeleton, and membrane lipids. The NIMA-related kinases NEKL-2 (human NEK8/9) and NEKL-3 (human NEK6/7) are conserved regulators of membrane trafficking in Caenorhabditis elegans that are required for the completion of molting. Using a genetic approach, we isolated reduction-of-function mutations in piki-1 that suppress nekl-associated molting defects. piki-1 encodes the sole predicted C. elegans Class II PI 3-kinase (PI3K), a relatively understudied class of lipid modifiers that contribute to the production of PI 3-phosphate (PI(3)P) and PI 3,4-bisphosphate (PI(3,4)P2). Using genetically encoded lipid sensors, we found that PIKI","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T09:58:09.077Z","creation":"2026-07-09T10:49:43.507Z"},"accession":"S-EPMC12919929","cross_references":{"pubmed":["41686813"],"doi":["10.1371/journal.pgen.1011740"]}}