{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(2)"],"submitter":["Nakano A"],"pubmed_abstract":["Pancreatic neuroendocrine tumors (PanNETs) represent a rare subset of pancreatic cancers, comprising approximately 1-2% of all cases. Non-functioning PanNETs (NF-PanNETs), which account for the majority of PanNETs, can be difficult to treat as they show no hormone-related symptoms and are often not diagnosed until more advanced stages. Current therapeutic agents have limited efficacy, highlighting the need for novel treatment strategies. Multiple endocrine neoplasia type 1 is a hereditary syndrome strongly associated with PanNETs and pituitary neuroendocrine tumors (PitNETs), caused by germline mutations in the MEN1 gene. Using Men1 f/f-RipCre+ mice, which develop both NF-PanNETs and PitNETs, we investigated whether long-term administration of metformin, a first-line anti-diabetic drug, co"],"journal":["Endocrine-related cancer"],"pagination":["e250518"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12920065"],"repository":["biostudies-literature"],"pubmed_title":["Metformin suppresses MEN1-associated pancreatic and pituitary neuroendocrine tumors: evidence from mouse models and clinical data."],"pmcid":["PMC12920065"],"pubmed_authors":["Moro T","Terada K","Tajima T","Ishiai M","Hoshino C","Nakano A","Shirai R","Hijioka S","Kassai H","Ohki R","Huang Y","Mistui Y","Tabata Y","Sakaguchi Y","Chen Y","Yokoyama A","Sakata N"],"additional_accession":[]},"is_claimable":false,"name":"Metformin suppresses MEN1-associated pancreatic and pituitary neuroendocrine tumors: evidence from mouse models and clinical data.","description":"Pancreatic neuroendocrine tumors (PanNETs) represent a rare subset of pancreatic cancers, comprising approximately 1-2% of all cases. Non-functioning PanNETs (NF-PanNETs), which account for the majority of PanNETs, can be difficult to treat as they show no hormone-related symptoms and are often not diagnosed until more advanced stages. Current therapeutic agents have limited efficacy, highlighting the need for novel treatment strategies. Multiple endocrine neoplasia type 1 is a hereditary syndrome strongly associated with PanNETs and pituitary neuroendocrine tumors (PitNETs), caused by germline mutations in the MEN1 gene. Using Men1 f/f-RipCre+ mice, which develop both NF-PanNETs and PitNETs, we investigated whether long-term administration of metformin, a first-line anti-diabetic drug, co","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T12:59:56.982Z","creation":"2026-07-09T10:57:04.384Z"},"accession":"S-EPMC12920065","cross_references":{"pubmed":["41568565"],"doi":["10.1530/ERC-25-0518"]}}