biostudies-literatureDoyle AMFondation Botnar494-504https://www.ebi.ac.uk/biostudies/studies/S-EPMC12920085biostudies-literatureUnknown32(2)Routine adolescent health check-ups can support healthy development and well-being, but evidence on the feasibility, acceptability and effectiveness of contextually relevant comprehensive check-ups in low- and middle-income settings is limited. We conducted a hybrid implementation-effectiveness study incorporating a mixed-methods pre-post design of Y-Check, a comprehensive health check-up intervention in Zimbabwe, as part of a multicountry study developed and coordinated by the World Health Organization. Eligible participants were 10-19-year-old adolescents attending school or community venues. We used self-administered digital questionnaires, provider-led clinical tests and nurse reviews to screen for 25 conditions/behaviors. We provided health promotion, on-site care and referral to releNature medicineImplementation and evaluation of the Y-Check comprehensive adolescent health check-up intervention in Zimbabwe: a pre-post mixed-methods study.PMC12920085RG21-001Nzvere FKasu TDziva Chikwari CBandason TWeiss HAChingono RMSNyamayaro WLi Lin IFerrand RASimms VMackworth-Young CRSManyau SKandiye FRTembo MBaltag VBernays SGreco GDauya ERoss DAManhibi RMaisiri HDoyle AMBanati PNyamayaro CATakawira MfalseImplementation and evaluation of the Y-Check comprehensive adolescent health check-up intervention in Zimbabwe: a pre-post mixed-methods study.Routine adolescent health check-ups can support healthy development and well-being, but evidence on the feasibility, acceptability and effectiveness of contextually relevant comprehensive check-ups in low- and middle-income settings is limited. We conducted a hybrid implementation-effectiveness study incorporating a mixed-methods pre-post design of Y-Check, a comprehensive health check-up intervention in Zimbabwe, as part of a multicountry study developed and coordinated by the World Health Organization. Eligible participants were 10-19-year-old adolescents attending school or community venues. We used self-administered digital questionnaires, provider-led clinical tests and nurse reviews to screen for 25 conditions/behaviors. We provided health promotion, on-site care and referral to rele2026-01-01T00:00:00Z2026 Feb2026-07-16T12:59:31.24Z2026-07-09T10:57:01.093ZS-EPMC129200854162942610.1038/s41591-025-04156-x