{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["99(1)"],"submitter":["Yokota K"],"pubmed_abstract":["<h4>Background</h4>We examined the underlying mechanisms of whether hyponatremia could be induced by hypotonic solution administration after the postoperative invasive phase (POIP).<h4>Methods</h4>We included patients who had undergone surgery with expected oral feeding resumption after postoperative day (POD) 3. In this open-label, randomized controlled trial, 100 patients were assigned to three groups by sodium concentrations ([Na]) used for maintenance infusions: 136 mEq/L (ISO) (n = 34), 68 mEq/L (HYPO) (n = 33), and 34 mEq/L (exHYPO) (n = 33). Potassium (20 mEq/L) and glucose (60 g/L) were added to each infusion. Ringer's solution was used in all groups for the first 12 h postoperatively, then switched to a maintenance solution. Blood samples were drawn and evaluated on POD 3.<h4>Resu"],"journal":["Pediatric research"],"pagination":["263-269"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12920089"],"repository":["biostudies-literature"],"pubmed_title":["Hyponatremia after pediatric surgery: Randomized trial of fluid composition on antidiuretic hormone response."],"pmcid":["PMC12920089"],"pubmed_authors":["Amano H","Nishiwaki K","Sumida W","Hinoki A","Nangaku M","Tainaka T","Hirai T","Ando M","Uchida H","Shirota C","Kuwatsuka Y","Yokota K","Makita S","Manaka K"],"additional_accession":[]},"is_claimable":false,"name":"Hyponatremia after pediatric surgery: Randomized trial of fluid composition on antidiuretic hormone response.","description":"<h4>Background</h4>We examined the underlying mechanisms of whether hyponatremia could be induced by hypotonic solution administration after the postoperative invasive phase (POIP).<h4>Methods</h4>We included patients who had undergone surgery with expected oral feeding resumption after postoperative day (POD) 3. In this open-label, randomized controlled trial, 100 patients were assigned to three groups by sodium concentrations ([Na]) used for maintenance infusions: 136 mEq/L (ISO) (n = 34), 68 mEq/L (HYPO) (n = 33), and 34 mEq/L (exHYPO) (n = 33). Potassium (20 mEq/L) and glucose (60 g/L) were added to each infusion. Ringer's solution was used in all groups for the first 12 h postoperatively, then switched to a maintenance solution. Blood samples were drawn and evaluated on POD 3.<h4>Resu","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T13:00:53.839Z","creation":"2026-07-09T10:56:30.765Z"},"accession":"S-EPMC12920089","cross_references":{"pubmed":["40399660"],"doi":["10.1038/s41390-025-04124-8"]}}