biostudies-literatureLi QEC | Horizon 2020 Framework ProgrammeEC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)259-276https://www.ebi.ac.uk/biostudies/studies/S-EPMC12920095biostudies-literatureUnknown10(2)Endoscopic detection of oesophageal cancer (EC) often occurs late in disease development, leading to high mortality rates. Improved technologies are urgently needed for earlier EC detection. Here we research an endoscopic ultra-broadband acoustic detection scheme and introduce a 360-degree hybrid optoacoustic and optical coherence endoscopy to enable interrogation of surface and subsurface precancerous and cancerous features at a three-dimensional micrometre scale. In the following pilot tissue investigation, the dual-modal imaging features are assessed for classifying different mucosal types in Barrett's oesophagus (BE)-a precursor of EC. We find that human lesions of different grades, such as metaplastic, dysplastic and cancerous mucosa, exhibit distinctly different imaging features thatNature biomedical engineeringTethered optoacoustic and optical coherence tomography capsule endoscopy for label-free assessment of Barrett's oesophageal neoplasia.PMC12920095No 732720 (ESOTRAC)No 721766 (FBI)Drexler WSarantos VPierre GGloriod JZakian CNtziachristos VFlisikowski KLi QO'Donovan Mdi Pietro MHoning JAli ZfalseTethered optoacoustic and optical coherence tomography capsule endoscopy for label-free assessment of Barrett's oesophageal neoplasia.Endoscopic detection of oesophageal cancer (EC) often occurs late in disease development, leading to high mortality rates. Improved technologies are urgently needed for earlier EC detection. Here we research an endoscopic ultra-broadband acoustic detection scheme and introduce a 360-degree hybrid optoacoustic and optical coherence endoscopy to enable interrogation of surface and subsurface precancerous and cancerous features at a three-dimensional micrometre scale. In the following pilot tissue investigation, the dual-modal imaging features are assessed for classifying different mucosal types in Barrett's oesophagus (BE)-a precursor of EC. We find that human lesions of different grades, such as metaplastic, dysplastic and cancerous mucosa, exhibit distinctly different imaging features that2026-01-01T00:00:00Z2026 Feb2026-07-16T13:05:09.874Z2026-07-09T10:56:29.005ZS-EPMC129200954077050410.1038/s41551-025-01462-0