{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["53(4)"],"submitter":["Speck I"],"pubmed_abstract":["<h4>Purpose</h4>We examined neuronal activation patterns in single-sided deaf (SSD) cochlear implant (CI) recipients and normal-hearing (NH) controls to unravel neuronal mechanisms underlying binaural integration in SSD-CI.<h4>Methods</h4>20 SSD-CI (CI left) and 10 NH controls underwent [<sup>15</sup>O]water PET (assessing relative cerebral blood flow, rCBF) during auditory stimulation (forward or time-reversed, unilaterally to NH ear or bilaterally). Subjects were divided into SSD-CI with good (≥ 80%) and poor (< 80%) performance based on a median split of correct word understanding in PET background noise. Voxel-wise analyses identified volumes of interest for regional analyses (right primary auditory cortex (PAC), left superior temporal gyrus (STG)) for volume-of-interest analyses.<h4>R"],"journal":["European journal of nuclear medicine and molecular imaging"],"pagination":["2751-2763"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12920324"],"repository":["biostudies-literature"],"pubmed_title":["Neuronal mechanisms underlying binaural performance with cochlear implant in single-sided deafness: a [&lt;sup&gt;15&lt;/sup&gt;O]water PET study."],"pmcid":["PMC12920324"],"pubmed_authors":["Wesarg T","Aschendorff A","Speck I","Arndt S","Meyer PT","Frings L","Blazhenets G","Thurow J"],"additional_accession":[]},"is_claimable":false,"name":"Neuronal mechanisms underlying binaural performance with cochlear implant in single-sided deafness: a [&lt;sup&gt;15&lt;/sup&gt;O]water PET study.","description":"<h4>Purpose</h4>We examined neuronal activation patterns in single-sided deaf (SSD) cochlear implant (CI) recipients and normal-hearing (NH) controls to unravel neuronal mechanisms underlying binaural integration in SSD-CI.<h4>Methods</h4>20 SSD-CI (CI left) and 10 NH controls underwent [<sup>15</sup>O]water PET (assessing relative cerebral blood flow, rCBF) during auditory stimulation (forward or time-reversed, unilaterally to NH ear or bilaterally). Subjects were divided into SSD-CI with good (≥ 80%) and poor (< 80%) performance based on a median split of correct word understanding in PET background noise. Voxel-wise analyses identified volumes of interest for regional analyses (right primary auditory cortex (PAC), left superior temporal gyrus (STG)) for volume-of-interest analyses.<h4>R","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Mar","modification":"2026-07-09T11:41:08.433Z","creation":"2026-07-09T10:54:54.73Z"},"accession":"S-EPMC12920324","cross_references":{"pubmed":["41240093"],"doi":["10.1007/s00259-025-07639-8"]}}