biostudies-literatureUnknown53(4)Speck I<h4>Purpose</h4>We examined neuronal activation patterns in single-sided deaf (SSD) cochlear implant (CI) recipients and normal-hearing (NH) controls to unravel neuronal mechanisms underlying binaural integration in SSD-CI.<h4>Methods</h4>20 SSD-CI (CI left) and 10 NH controls underwent [<sup>15</sup>O]water PET (assessing relative cerebral blood flow, rCBF) during auditory stimulation (forward or time-reversed, unilaterally to NH ear or bilaterally). Subjects were divided into SSD-CI with good (≥ 80%) and poor (< 80%) performance based on a median split of correct word understanding in PET background noise. Voxel-wise analyses identified volumes of interest for regional analyses (right primary auditory cortex (PAC), left superior temporal gyrus (STG)) for volume-of-interest analyses.<h4>REuropean journal of nuclear medicine and molecular imaging2751-2763https://www.ebi.ac.uk/biostudies/studies/S-EPMC12920324biostudies-literatureNeuronal mechanisms underlying binaural performance with cochlear implant in single-sided deafness: a [&lt;sup&gt;15&lt;/sup&gt;O]water PET study.PMC12920324Wesarg TAschendorff ASpeck IArndt SMeyer PTFrings LBlazhenets GThurow JfalseNeuronal mechanisms underlying binaural performance with cochlear implant in single-sided deafness: a [&lt;sup&gt;15&lt;/sup&gt;O]water PET study.<h4>Purpose</h4>We examined neuronal activation patterns in single-sided deaf (SSD) cochlear implant (CI) recipients and normal-hearing (NH) controls to unravel neuronal mechanisms underlying binaural integration in SSD-CI.<h4>Methods</h4>20 SSD-CI (CI left) and 10 NH controls underwent [<sup>15</sup>O]water PET (assessing relative cerebral blood flow, rCBF) during auditory stimulation (forward or time-reversed, unilaterally to NH ear or bilaterally). Subjects were divided into SSD-CI with good (≥ 80%) and poor (< 80%) performance based on a median split of correct word understanding in PET background noise. Voxel-wise analyses identified volumes of interest for regional analyses (right primary auditory cortex (PAC), left superior temporal gyrus (STG)) for volume-of-interest analyses.<h4>R2026-01-01T00:00:00Z2026 Mar2026-07-09T11:41:08.433Z2026-07-09T10:54:54.73ZS-EPMC129203244124009310.1007/s00259-025-07639-8