biostudies-literatureUnknown13Nguyen TC<h4>Background</h4>Moderate-to-severe coronary artery calcification (CAC) poses major challenges during percutaneous coronary intervention (PCI) and has historically been associated with procedural failure and adverse outcomes. However, its prognostic relevance in the era of contemporary intravascular imaging-guided PCI remains uncertain. This study aimed to evaluate the impact of moderate-to-severe CAC on 1-year clinical outcomes after IVUS-guided PCI.<h4>Methods</h4>This prospective, single-center study enrolled 914 patients who underwent IVUS-guided PCI between March and November 2023. CAC severity was classified by IVUS as none/mild or moderate-to-severe. After 1:1 propensity score matching, 576 patients (288 per group) were included. The primary endpoint was 1-year major adverse cardiFrontiers in cardiovascular medicine1720958https://www.ebi.ac.uk/biostudies/studies/S-EPMC12920530biostudies-literatureImpact of moderate-to-severe coronary calcification on 1-year clinical outcomes after IVUS-guided PCI.PMC12920530Nguyen TCVu VHLe KMTruong BQNgo HMTran HDuong BTHoang VNguyen TQfalseImpact of moderate-to-severe coronary calcification on 1-year clinical outcomes after IVUS-guided PCI.<h4>Background</h4>Moderate-to-severe coronary artery calcification (CAC) poses major challenges during percutaneous coronary intervention (PCI) and has historically been associated with procedural failure and adverse outcomes. However, its prognostic relevance in the era of contemporary intravascular imaging-guided PCI remains uncertain. This study aimed to evaluate the impact of moderate-to-severe CAC on 1-year clinical outcomes after IVUS-guided PCI.<h4>Methods</h4>This prospective, single-center study enrolled 914 patients who underwent IVUS-guided PCI between March and November 2023. CAC severity was classified by IVUS as none/mild or moderate-to-severe. After 1:1 propensity score matching, 576 patients (288 per group) were included. The primary endpoint was 1-year major adverse cardi2026-01-01T00:00:00Z20262026-07-16T18:37:05.496Z2026-07-09T11:15:20.532ZS-EPMC129205304172593110.3389/fcvm.2026.1720958