biostudies-literatureCastells AInstituto de Salud Carlos IIIFundación Científica Asociación Española Contra el Cáncere70169https://www.ebi.ac.uk/biostudies/studies/S-EPMC12920682biostudies-literatureUnknown14(2)<h4>Background</h4>Colorectal cancer (CRC) screening is effective and cost-effective in average-risk individuals. The COLONPREV study recently showed that individuals invited to a faecal immunochemical test (FIT) were more likely to participate in screening than those invited to colonoscopy, and that FIT-based screening was non-inferior to colonoscopy with respect to CRC-related mortality and CRC incidence.<h4>Objective</h4>To assess whether the outcomes of colonoscopy- and FIT-based screening differ according to sex and age in the invited population.<h4>Methods</h4>Presumptively healthy men and women aged 50-69 years were randomised to either a one-time screening colonoscopy or biennial FIT. In this analysis, we report participation and crossover rates, CRC-related mortality, CRC incidencUnited European gastroenterology journalSex- and Age-Stratified Outcomes of Colonoscopy Versus Faecal Immunochemical Testing: Post-Analysis of the COLONPREV Study.PMC12920682GCB13131592CASTPI08/90717AECC07185Cubiella JMorillas JDBujanda LColl-Vinent BCastan-Cameo SAndreu MDiaz-Tasende JCastells ASerra-Burriel MCOLONPREV study investigatorsJover RLanas ACarballo FFrias-Arrocha EOno AQuintero EHernandez CSalas DfalseSex- and Age-Stratified Outcomes of Colonoscopy Versus Faecal Immunochemical Testing: Post-Analysis of the COLONPREV Study.<h4>Background</h4>Colorectal cancer (CRC) screening is effective and cost-effective in average-risk individuals. The COLONPREV study recently showed that individuals invited to a faecal immunochemical test (FIT) were more likely to participate in screening than those invited to colonoscopy, and that FIT-based screening was non-inferior to colonoscopy with respect to CRC-related mortality and CRC incidence.<h4>Objective</h4>To assess whether the outcomes of colonoscopy- and FIT-based screening differ according to sex and age in the invited population.<h4>Methods</h4>Presumptively healthy men and women aged 50-69 years were randomised to either a one-time screening colonoscopy or biennial FIT. In this analysis, we report participation and crossover rates, CRC-related mortality, CRC incidenc2026-01-01T00:00:00Z2026 Mar2026-07-16T15:09:50.541Z2026-07-09T11:03:31.557ZS-EPMC129206824171525010.1002/ueg2.70169