{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Watanabe T"],"funding":["Tokai University School of Medicine Research Aid","Japan Society for the Promotion of Science"],"pagination":["7112"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12920786"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Ultraviolet (UV) radiation is a major environmental factor that induces DNA lesions. Cells have evolved repair pathways, in which the transcription-coupled nucleotide excision repair (TC-NER) has a central role in removing the lesions. Here we demonstrate that DGCR8, known as a crucial component in microRNA biogenesis, coordinates the UV-induced formation of the TC-NER complex by interacting with TC-NER factors. These interactions could depend on the phosphorylation of Serine 153 of DGCR8, potentially serving as a functional switch from miRNA biogenesis to the TC-NER process. Interestingly, DGCR8 is also involved in recruiting chromatin remodelers, SPT16 and SMARCA5, for the TC-NER initiation, regulating UV-induced DNA/RNA hybrids (R-loops), and modulating DNA replication through the ATR-C"],"journal":["Scientific reports"],"pubmed_title":["DGCR8 regulates multiple processes of transcription coupled nucleotide excision repair."],"pmcid":["PMC12920786"],"funding_grant_id":["2018, 2019, 2021 and 2023","KAKENHI 15K21771, 23K21303","KAKENHI 23K21303, 19K06493, 24K15292","2022 and 2023"],"pubmed_authors":["Tanaka Y","Watanabe T","Yamasaki H","Ohtsuka M","Taniguchi T","Yoshinami D"],"additional_accession":[]},"is_claimable":false,"name":"DGCR8 regulates multiple processes of transcription coupled nucleotide excision repair.","description":"Ultraviolet (UV) radiation is a major environmental factor that induces DNA lesions. Cells have evolved repair pathways, in which the transcription-coupled nucleotide excision repair (TC-NER) has a central role in removing the lesions. Here we demonstrate that DGCR8, known as a crucial component in microRNA biogenesis, coordinates the UV-induced formation of the TC-NER complex by interacting with TC-NER factors. These interactions could depend on the phosphorylation of Serine 153 of DGCR8, potentially serving as a functional switch from miRNA biogenesis to the TC-NER process. Interestingly, DGCR8 is also involved in recruiting chromatin remodelers, SPT16 and SMARCA5, for the TC-NER initiation, regulating UV-induced DNA/RNA hybrids (R-loops), and modulating DNA replication through the ATR-C","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T12:59:26.66Z","creation":"2026-07-09T10:57:00.35Z"},"accession":"S-EPMC12920786","cross_references":{"pubmed":["41634336"],"doi":["10.1038/s41598-026-38338-5"]}}