{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["34(3)"],"submitter":["Carvalheiro R"],"pubmed_abstract":["<h4>Background</h4>Functional mitral regurgitation (FMR) contributes significantly to morbidity and mortality and may result from left ventricular (VFMR) or atrial (AFMR) remodelling. Left atrial reservoir strain (LASR) is a sensitive marker of atrial dysfunction and may offer incremental prognostic value. This study evaluated whether LASR predicts all-cause mortality and heart failure (HF) hospitalizations in FMR, its performance in VFMR versus AFMR, and its utility over standard echocardiographic parameters.<h4>Methods</h4>We retrospectively analyzed 102 patients (mean age 68 ± 14 years, 41.2% female) with at least moderate FMR who underwent transesophageal echocardiography between 2018 and 2023. Patients were categorized into VFMR (LV dysfunction or remodelling) and AFMR (LA enlargement"],"journal":["Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation"],"pagination":["117-123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12920826"],"repository":["biostudies-literature"],"pubmed_title":["Left atrial reservoir strain by speckle-tracking echocardiography predicts prognosis in secondary mitral valve insufficiency."],"pmcid":["PMC12920826"],"pubmed_authors":["Vaz Ferreira V","Mano T","Leal A","Galrinho AI","Aguiar Rosa S","Gameiro F","Viegas J","Marques Antunes M","Carvalheiro R","Cruz Ferreira R","Cardoso I","Rio P","Timoteo AT"],"additional_accession":[]},"is_claimable":false,"name":"Left atrial reservoir strain by speckle-tracking echocardiography predicts prognosis in secondary mitral valve insufficiency.","description":"<h4>Background</h4>Functional mitral regurgitation (FMR) contributes significantly to morbidity and mortality and may result from left ventricular (VFMR) or atrial (AFMR) remodelling. Left atrial reservoir strain (LASR) is a sensitive marker of atrial dysfunction and may offer incremental prognostic value. This study evaluated whether LASR predicts all-cause mortality and heart failure (HF) hospitalizations in FMR, its performance in VFMR versus AFMR, and its utility over standard echocardiographic parameters.<h4>Methods</h4>We retrospectively analyzed 102 patients (mean age 68 ± 14 years, 41.2% female) with at least moderate FMR who underwent transesophageal echocardiography between 2018 and 2023. Patients were categorized into VFMR (LV dysfunction or remodelling) and AFMR (LA enlargement","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Mar","modification":"2026-07-16T12:28:04.569Z","creation":"2026-07-09T10:54:11.709Z"},"accession":"S-EPMC12920826","cross_references":{"pubmed":["41627690"],"doi":["10.1007/s12471-026-02022-0"]}}