biostudies-literatureUnknown34(3)Carvalheiro R<h4>Background</h4>Functional mitral regurgitation (FMR) contributes significantly to morbidity and mortality and may result from left ventricular (VFMR) or atrial (AFMR) remodelling. Left atrial reservoir strain (LASR) is a sensitive marker of atrial dysfunction and may offer incremental prognostic value. This study evaluated whether LASR predicts all-cause mortality and heart failure (HF) hospitalizations in FMR, its performance in VFMR versus AFMR, and its utility over standard echocardiographic parameters.<h4>Methods</h4>We retrospectively analyzed 102 patients (mean age 68 ± 14 years, 41.2% female) with at least moderate FMR who underwent transesophageal echocardiography between 2018 and 2023. Patients were categorized into VFMR (LV dysfunction or remodelling) and AFMR (LA enlargementNetherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation117-123https://www.ebi.ac.uk/biostudies/studies/S-EPMC12920826biostudies-literatureLeft atrial reservoir strain by speckle-tracking echocardiography predicts prognosis in secondary mitral valve insufficiency.PMC12920826Vaz Ferreira VMano TLeal AGalrinho AIAguiar Rosa SGameiro FViegas JMarques Antunes MCarvalheiro RCruz Ferreira RCardoso IRio PTimoteo ATfalseLeft atrial reservoir strain by speckle-tracking echocardiography predicts prognosis in secondary mitral valve insufficiency.<h4>Background</h4>Functional mitral regurgitation (FMR) contributes significantly to morbidity and mortality and may result from left ventricular (VFMR) or atrial (AFMR) remodelling. Left atrial reservoir strain (LASR) is a sensitive marker of atrial dysfunction and may offer incremental prognostic value. This study evaluated whether LASR predicts all-cause mortality and heart failure (HF) hospitalizations in FMR, its performance in VFMR versus AFMR, and its utility over standard echocardiographic parameters.<h4>Methods</h4>We retrospectively analyzed 102 patients (mean age 68 ± 14 years, 41.2% female) with at least moderate FMR who underwent transesophageal echocardiography between 2018 and 2023. Patients were categorized into VFMR (LV dysfunction or remodelling) and AFMR (LA enlargement2026-01-01T00:00:00Z2026 Mar2026-07-16T12:28:04.569Z2026-07-09T10:54:11.709ZS-EPMC129208264162769010.1007/s12471-026-02022-0