{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang L"],"funding":["Breast Cancer Research Foundation","National Cancer Institute","NCI NIH HHS","National Cancer Institute, United States","Basser Center"],"pagination":["27"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12920871"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["We utilized the K14-Cre Brca1<sup>f/f</sup>Tp53<sup>f/f</sup> mouse model to investigate whether a pulse of PARP inhibitor (PARPi) ± an AKT inhibitor (AKTi) can prevent Brca1-related breast cancer. PARPi alone did not intercept or prevent tumor development. PARPi+AKTi intercepted tumors but did not prevent new tumors. These data confirm the efficacy of a PARPi and an inhibitor of PI3K signaling in treating BRCA1/2-related tumors, but this combination is not sufficient to prevent carcinogenesis."],"journal":["NPJ breast cancer"],"pubmed_title":["Simultaneous inhibition of PARP/AKT to intercept nascent BRCA1/2&lt;sup&gt;mut&lt;/sup&gt; breast tumors."],"pmcid":["PMC12920871"],"funding_grant_id":["25-177","R21CA267088","R56CA284564","R01CA226776"],"pubmed_authors":["Li X","Liu Z","Wulf GM","Sardella BR","Heng YJ","Wang L","Aronson EK"],"additional_accession":[]},"is_claimable":false,"name":"Simultaneous inhibition of PARP/AKT to intercept nascent BRCA1/2&lt;sup&gt;mut&lt;/sup&gt; breast tumors.","description":"We utilized the K14-Cre Brca1<sup>f/f</sup>Tp53<sup>f/f</sup> mouse model to investigate whether a pulse of PARP inhibitor (PARPi) ± an AKT inhibitor (AKTi) can prevent Brca1-related breast cancer. PARPi alone did not intercept or prevent tumor development. PARPi+AKTi intercepted tumors but did not prevent new tumors. These data confirm the efficacy of a PARPi and an inhibitor of PI3K signaling in treating BRCA1/2-related tumors, but this combination is not sufficient to prevent carcinogenesis.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T12:59:14.898Z","creation":"2026-07-09T10:56:58.806Z"},"accession":"S-EPMC12920871","cross_references":{"pubmed":["41545354"],"doi":["10.1038/s41523-026-00892-6"]}}