{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shine EE"],"funding":["Life Sciences Research Foundation","Howard Hughes Medical Institute","National Institutes of Health (NIH)","National Science Foundation (NSF)"],"pagination":["6258-6269"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12921845"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["148(6)"],"pubmed_abstract":["Bacteria use small molecules to orchestrate collective behaviors in a process called quorum sensing (QS), which relies on the production, release, and group-wide detection of extracellular signal molecules referred to as autoinducers. One QS autoinducer, termed AI-2, is broadly used for interspecies bacterial communication, including in the mammalian gut. AI-2 consists of a family of interconverting compounds and adducts originating from 4,5-dihydroxy-2,3-pentanedione. This complex speciation, coupled with the inherent instability of AI-2 congeners, have complicated isolation efforts. It has been known that mammalian epithelial cells produce an AI-2 mimic to which bacteria respond. However, the identity of the AI-2 mimic has remained elusive, presumably due to its instability, similar to t"],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Discovery of a Human Metabolite That Mimics the Bacterial Quorum-Sensing Autoinducer AI-2."],"pmcid":["PMC12921845"],"funding_grant_id":["R21AT013123","MCB-2508324","R37GM065859"],"pubmed_authors":["Huang JZ","Shine EE","Valastyan JS","Seyedsayamdost MR","Ying VY","Bassler BL"],"additional_accession":[]},"is_claimable":false,"name":"Discovery of a Human Metabolite That Mimics the Bacterial Quorum-Sensing Autoinducer AI-2.","description":"Bacteria use small molecules to orchestrate collective behaviors in a process called quorum sensing (QS), which relies on the production, release, and group-wide detection of extracellular signal molecules referred to as autoinducers. One QS autoinducer, termed AI-2, is broadly used for interspecies bacterial communication, including in the mammalian gut. AI-2 consists of a family of interconverting compounds and adducts originating from 4,5-dihydroxy-2,3-pentanedione. This complex speciation, coupled with the inherent instability of AI-2 congeners, have complicated isolation efforts. It has been known that mammalian epithelial cells produce an AI-2 mimic to which bacteria respond. However, the identity of the AI-2 mimic has remained elusive, presumably due to its instability, similar to t","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T15:11:40.896Z","creation":"2026-07-09T11:03:47.359Z"},"accession":"S-EPMC12921845","cross_references":{"pubmed":["41638709"],"doi":["10.1021/jacs.5c18527"]}}