biostudies-literatureKan SYTaichung Armed Forces Research Foundation36https://www.ebi.ac.uk/biostudies/studies/S-EPMC12922018biostudies-literatureUnknown9(1)<b>Background and Clinical Significance</b>: Oral ulcers are a common disease for dental practitioners. The policy of treating oral ulcers includes removing etiology and medication. Standard management of oral ulcers includes elimination of etiologic factors and pharmacologic therapy. Topical corticosteroids are the most commonly used medicine for oral ulcers. Exclude possible etiologies related to ulcers; refractory ulcers need systemic evaluation and precise medication use to improve patients' quality and satisfaction. <b>Case Presentation</b>: We present a case of refractory oral ulcers resistant to multiple conventional treatments, which were found to be ineffective. These ulcers significantly impact patient quality of life. We prescribed a series of oral ulcer treatments following theReports (MDPI)Successful Remission of Refractory Oral Ulcers Treated with Low-Dose Thalidomide and Colchicine: A Case Report.PMC12922018TCAFGH_E_114037Chiu KCHsu CLKan SYSung YKfalseSuccessful Remission of Refractory Oral Ulcers Treated with Low-Dose Thalidomide and Colchicine: A Case Report.<b>Background and Clinical Significance</b>: Oral ulcers are a common disease for dental practitioners. The policy of treating oral ulcers includes removing etiology and medication. Standard management of oral ulcers includes elimination of etiologic factors and pharmacologic therapy. Topical corticosteroids are the most commonly used medicine for oral ulcers. Exclude possible etiologies related to ulcers; refractory ulcers need systemic evaluation and precise medication use to improve patients' quality and satisfaction. <b>Case Presentation</b>: We present a case of refractory oral ulcers resistant to multiple conventional treatments, which were found to be ineffective. These ulcers significantly impact patient quality of life. We prescribed a series of oral ulcer treatments following the2026-01-01T00:00:00Z2026 Jan2026-07-09T11:46:00.046Z2026-07-09T10:57:00.931ZS-EPMC129220184171828710.3390/reports9010036