biostudies-literatureAnilkumar ANational Institute of Arthritis and Musculoskeletal and Skin DiseasesU.S. Department of DefenseNational Institutes of HealthNIAMS NIH HHS152593https://www.ebi.ac.uk/biostudies/studies/S-EPMC12922703biostudies-literatureUnknown70Cutaneous telangiectasia (Tel) are visible permanently dilated postcapillary dermal venules and are one of the most common disease-specific manifestations of systemic sclerosis (SSc). Telangiectasia have long been recognised for their utility in the diagnosis and classification of SSc, but the clinical and prognostic relevance of these aberrant cutaneous vascular manifestations has been somewhat neglected by clinicians. Similarly, the impact of SSc-Tel on body image dissatisfaction and social discomfort has been under-appreciated. The paucity of evidence-based approaches to management has limited access to potential effective treatments for SSc-Tel. The present review examines the pathogenesis, diagnostic value, impact and clinical relevance of telangiectasia in SSc. We highlight the potenSeminars in arthritis and rheumatismThe pathogenesis, diagnostic utility and clinical relevance of cutaneous telangiectasia in systemic sclerosis.PMC12922703K24 AR080217W81XWH-18-1-0602Anilkumar APauling JDShah AAHummers LKWells MDomsic RTfalseThe pathogenesis, diagnostic utility and clinical relevance of cutaneous telangiectasia in systemic sclerosis.Cutaneous telangiectasia (Tel) are visible permanently dilated postcapillary dermal venules and are one of the most common disease-specific manifestations of systemic sclerosis (SSc). Telangiectasia have long been recognised for their utility in the diagnosis and classification of SSc, but the clinical and prognostic relevance of these aberrant cutaneous vascular manifestations has been somewhat neglected by clinicians. Similarly, the impact of SSc-Tel on body image dissatisfaction and social discomfort has been under-appreciated. The paucity of evidence-based approaches to management has limited access to potential effective treatments for SSc-Tel. The present review examines the pathogenesis, diagnostic value, impact and clinical relevance of telangiectasia in SSc. We highlight the poten2025-01-01T00:00:00Z2025 Feb2026-07-16T12:58:05.567Z2026-07-09T10:56:50.79ZS-EPMC129227033958618310.1016/j.semarthrit.2024.152593