{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mustra Rakic J"],"funding":["NIDA NIH HHS"],"pagination":["1129-1138"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12922773"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(4)"],"pubmed_abstract":["<h4>Background</h4>The apolipoprotein L1 (APOL1) G1 and G2 gene variants, highly prevalent among the African American population (rare in other racial groups), are linked to increased risk of kidney disease, sepsis, and potentially coronary heart disease (CHD). Their role in tobacco-related CHD remains unclear.<h4>Objective</h4>To investigate the effect of APOL1 risk variants on the association between tobacco smoking and prevalent CHD in African American adults.<h4>Methods</h4>We conducted a cross-sectional study involving 519 African American adults recruited through the University of California San Francisco Lipid Clinic. Using multivariable logistic regression, we assessed the association between tobacco smoking and CHD, overall and with its most severe subtype, myocardial infarction ("],"journal":["Journal of clinical lipidology"],"pubmed_title":["Increased prevalence of coronary heart disease among current smokers carrying APOL1 risk variants within the African American population."],"pmcid":["PMC12922773"],"funding_grant_id":["T32 DA057216"],"pubmed_authors":["Mustra Rakic J","Van Blarigan EL","Pullinger CR","Stock EO","Malloy MJ","Kane JP","Movsesyan I"],"additional_accession":[]},"is_claimable":false,"name":"Increased prevalence of coronary heart disease among current smokers carrying APOL1 risk variants within the African American population.","description":"<h4>Background</h4>The apolipoprotein L1 (APOL1) G1 and G2 gene variants, highly prevalent among the African American population (rare in other racial groups), are linked to increased risk of kidney disease, sepsis, and potentially coronary heart disease (CHD). Their role in tobacco-related CHD remains unclear.<h4>Objective</h4>To investigate the effect of APOL1 risk variants on the association between tobacco smoking and prevalent CHD in African American adults.<h4>Methods</h4>We conducted a cross-sectional study involving 519 African American adults recruited through the University of California San Francisco Lipid Clinic. Using multivariable logistic regression, we assessed the association between tobacco smoking and CHD, overall and with its most severe subtype, myocardial infarction (","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul-Aug","modification":"2026-07-16T15:11:08.187Z","creation":"2026-07-09T11:03:05.087Z"},"accession":"S-EPMC12922773","cross_references":{"pubmed":["40360375"],"doi":["10.1016/j.jacl.2025.04.189"]}}