{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(2)"],"submitter":["Falco-Roget A"],"pubmed_abstract":["Background
The diagnosis of P. jirovecii pneumonia (PJP) in immunosuppressed, HIV-negative patients is often limited by the inability to perform a bronchoalveolar lavage (BAL) due to respiratory insufficiency. In this study, we evaluated the diagnostic accuracy of combining serum beta-D-glucan (BDG) testing with P. jirovecii polymerase chain reaction (PCR) in oral wash (OW) samples as noninvasive tools for PJP diagnosis.Methods
This was a retrospective, single-center study including all immunosuppressed non-HIV adult patients with suspected PJP in whom a Fujifilm Wako β-glucan test BDG and BAL PJ in-house PCR determination were performed during a 5-year period (2019-2024). The diagnostic performance (negative predictive value [NPV], positive predictive value ["],"journal":["Open forum infectious diseases"],"pagination":["ofag033"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12923328"],"repository":["biostudies-literature"],"pubmed_title":["Combined Serum (1,3)-β-D-Glucan and Oral Wash PCR as a Noninvasive Diagnostic Strategy for Early Detection of <i>Pneumocystis jirovecii</i> Pneumonia: An Observational Retrospective Study."],"pmcid":["PMC12923328"],"pubmed_authors":["Falco-Roget A","Serradell S","Revilla E","Perez-Gonzalez A","Los-Arcos I","Diaz-Lagares C","Ruiz-Camps I","Albasanz-Puig A","Guillen A","Len O","Martin-Gomez MT"],"additional_accession":[]},"is_claimable":false,"name":"Combined Serum (1,3)-β-D-Glucan and Oral Wash PCR as a Noninvasive Diagnostic Strategy for Early Detection of <i>Pneumocystis jirovecii</i> Pneumonia: An Observational Retrospective Study.","description":"Background
The diagnosis of P. jirovecii pneumonia (PJP) in immunosuppressed, HIV-negative patients is often limited by the inability to perform a bronchoalveolar lavage (BAL) due to respiratory insufficiency. In this study, we evaluated the diagnostic accuracy of combining serum beta-D-glucan (BDG) testing with P. jirovecii polymerase chain reaction (PCR) in oral wash (OW) samples as noninvasive tools for PJP diagnosis.Methods
This was a retrospective, single-center study including all immunosuppressed non-HIV adult patients with suspected PJP in whom a Fujifilm Wako β-glucan test BDG and BAL PJ in-house PCR determination were performed during a 5-year period (2019-2024). The diagnostic performance (negative predictive value [NPV], positive predictive value [","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T17:40:09.949Z","creation":"2026-07-09T11:08:32.795Z"},"accession":"S-EPMC12923328","cross_references":{"pubmed":["41725705"],"doi":["10.1093/ofid/ofag033"]}}