{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jellema PEJ"],"funding":["European Research Council","Alzheimer Nederland","Hanarth Fonds","Galen and Hilary Weston Foundation"],"pagination":["e70250"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12923661"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39(4)"],"pubmed_abstract":["Cerebellar mutism syndrome (CMS) is a potential complication of pediatric posterior fossa tumor (pPFT) resection and may be related to disruption of the dentato-rubro-thalamic tract (DRTT). Intraoperative tractography allows assessment of changes to the DRTT during surgery. We evaluated macro- and microstructural changes of the DRTT by comparing pre- and intraoperative diffusion MRI (dMRI) tractography in patients with pPFT. Pre- and intraoperative T1-weighted and dMRI data were acquired to reconstruct the DRTT, while the arcuate fasciculus (AF) was reconstructed as a control tract. To evaluate macrostructural intraoperative alterations, tract volume and diameter were calculated. Microstructural changes were assessed using fractional anisotropy (FA) and mean diffusivity (MD), both globally"],"journal":["NMR in biomedicine"],"pubmed_title":["Structural Fiber Tract Alterations in Relation to Surgery in Children With a Posterior Fossa Tumor."],"pmcid":["PMC12923661"],"funding_grant_id":["WE.03-2022-11","101163214"],"pubmed_authors":["Kersbergen KJ","Nieuwenhuis WP","Lequin MH","Hoving EW","Froeling M","Jellema PEJ","De Luca A","Wijnen JP"],"additional_accession":[]},"is_claimable":false,"name":"Structural Fiber Tract Alterations in Relation to Surgery in Children With a Posterior Fossa Tumor.","description":"Cerebellar mutism syndrome (CMS) is a potential complication of pediatric posterior fossa tumor (pPFT) resection and may be related to disruption of the dentato-rubro-thalamic tract (DRTT). Intraoperative tractography allows assessment of changes to the DRTT during surgery. We evaluated macro- and microstructural changes of the DRTT by comparing pre- and intraoperative diffusion MRI (dMRI) tractography in patients with pPFT. Pre- and intraoperative T1-weighted and dMRI data were acquired to reconstruct the DRTT, while the arcuate fasciculus (AF) was reconstructed as a control tract. To evaluate macrostructural intraoperative alterations, tract volume and diameter were calculated. Microstructural changes were assessed using fractional anisotropy (FA) and mean diffusivity (MD), both globally","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Apr","modification":"2026-07-16T14:53:56.338Z","creation":"2026-07-09T11:01:19.777Z"},"accession":"S-EPMC12923661","cross_references":{"pubmed":["41721469"],"doi":["10.1002/nbm.70250"]}}