biostudies-literatureJellema PEJEuropean Research CouncilAlzheimer NederlandHanarth FondsGalen and Hilary Weston Foundatione70250https://www.ebi.ac.uk/biostudies/studies/S-EPMC12923661biostudies-literatureUnknown39(4)Cerebellar mutism syndrome (CMS) is a potential complication of pediatric posterior fossa tumor (pPFT) resection and may be related to disruption of the dentato-rubro-thalamic tract (DRTT). Intraoperative tractography allows assessment of changes to the DRTT during surgery. We evaluated macro- and microstructural changes of the DRTT by comparing pre- and intraoperative diffusion MRI (dMRI) tractography in patients with pPFT. Pre- and intraoperative T1-weighted and dMRI data were acquired to reconstruct the DRTT, while the arcuate fasciculus (AF) was reconstructed as a control tract. To evaluate macrostructural intraoperative alterations, tract volume and diameter were calculated. Microstructural changes were assessed using fractional anisotropy (FA) and mean diffusivity (MD), both globallyNMR in biomedicineStructural Fiber Tract Alterations in Relation to Surgery in Children With a Posterior Fossa Tumor.PMC12923661WE.03-2022-11101163214Kersbergen KJNieuwenhuis WPLequin MHHoving EWFroeling MJellema PEJDe Luca AWijnen JPfalseStructural Fiber Tract Alterations in Relation to Surgery in Children With a Posterior Fossa Tumor.Cerebellar mutism syndrome (CMS) is a potential complication of pediatric posterior fossa tumor (pPFT) resection and may be related to disruption of the dentato-rubro-thalamic tract (DRTT). Intraoperative tractography allows assessment of changes to the DRTT during surgery. We evaluated macro- and microstructural changes of the DRTT by comparing pre- and intraoperative diffusion MRI (dMRI) tractography in patients with pPFT. Pre- and intraoperative T1-weighted and dMRI data were acquired to reconstruct the DRTT, while the arcuate fasciculus (AF) was reconstructed as a control tract. To evaluate macrostructural intraoperative alterations, tract volume and diameter were calculated. Microstructural changes were assessed using fractional anisotropy (FA) and mean diffusivity (MD), both globally2026-01-01T00:00:00Z2026 Apr2026-07-16T14:53:56.338Z2026-07-09T11:01:19.777ZS-EPMC129236614172146910.1002/nbm.70250