{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shao Y"],"funding":["Key Projects of General Hospital of Northern Theater Command"],"pagination":["7326"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12923675"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Interleukin 7 (IL‑7) regulates lymphangiogenesis and proliferation, inhibits apoptosis and autophagy in non‑small cell lung cancer (NSCLC). However, the role and detailed molecular mechanism of IL‑7 involved in NSCLC epithelial-to-mesenchymal transition (EMT) remain unknown. In this study, 119 cases of NSCLC tissue specimens were used to determine the expression levels and prognostic values of IL-7, IL-7R, E-cadherin and Vimentin. The CCK8, wound healing and transwell migration and invasion assays were employed to detect the NSCLC cell proliferation, migration and invasion, respectively. A subcutaneous tumor model and tail vein tumor injection in C57BL/6J mice were used to assess the role of IL-7 in vivo. Western blot, qRT-PCR and phalloidin staining assays were performed to investigate th"],"journal":["Scientific reports"],"pubmed_title":["Interleukin-7 induces EMT to promote tumor growth and metastasis in NSCLC via Notch1/TGF-β pathway."],"pmcid":["PMC12923675"],"funding_grant_id":["No: ZZKY2024037"],"pubmed_authors":["Li X","Li C","Shao Y","Ni W","Fu Y","Cheng H","Zhang A","Ming J"],"additional_accession":[]},"is_claimable":false,"name":"Interleukin-7 induces EMT to promote tumor growth and metastasis in NSCLC via Notch1/TGF-β pathway.","description":"Interleukin 7 (IL‑7) regulates lymphangiogenesis and proliferation, inhibits apoptosis and autophagy in non‑small cell lung cancer (NSCLC). However, the role and detailed molecular mechanism of IL‑7 involved in NSCLC epithelial-to-mesenchymal transition (EMT) remain unknown. In this study, 119 cases of NSCLC tissue specimens were used to determine the expression levels and prognostic values of IL-7, IL-7R, E-cadherin and Vimentin. The CCK8, wound healing and transwell migration and invasion assays were employed to detect the NSCLC cell proliferation, migration and invasion, respectively. A subcutaneous tumor model and tail vein tumor injection in C57BL/6J mice were used to assess the role of IL-7 in vivo. Western blot, qRT-PCR and phalloidin staining assays were performed to investigate th","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-09T11:53:14.303Z","creation":"2026-07-09T11:01:15.718Z"},"accession":"S-EPMC12923675","cross_references":{"pubmed":["41644700"],"doi":["10.1038/s41598-026-37876-2"]}}