{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["83"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12923772"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>Mitochondrial dysfunction has been implicated in major depressive disorder (MDD), but reliable, measurable biomarkers remain elusive. As a minimally invasive and quantifiable biomarker, circulating cell-free mitochondrial DNA (ccf-mtDNA) in blood offers potential for objective assessment of mitochondrial stress in MDD. However, evidence linking regarding the association between ccf-mtDNA levels and MDD is limited and inconsistent.<h4>Methods</h4>We systematically searched eight databases, including PubMed, EMBASE, and major Chinese repositories. Thirteen studies with 1370 participants (837 individuals with MDD and 533 controls) were included per PRISMA guidelines. P-values were synthesized using the Lipták-Stouffer Z-score method. Sensitivity and fail-safe N analyses ass"],"journal":["Translational psychiatry"],"pubmed_title":["Blood circulating cell-free mitochondrial DNA as a potential biomarker for major depressive disorder: a meta-analysis."],"pmcid":["PMC12923772"],"funding_grant_id":["82301709","82371524","81920108018, 82230046"],"pubmed_authors":["Zhao M","Chen Q","Li T","Zhang Y","Qi X","Guo W","Song S","Wei W","Meng Y","Deng W","Yu X"],"additional_accession":[]},"is_claimable":false,"name":"Blood circulating cell-free mitochondrial DNA as a potential biomarker for major depressive disorder: a meta-analysis.","description":"<h4>Background</h4>Mitochondrial dysfunction has been implicated in major depressive disorder (MDD), but reliable, measurable biomarkers remain elusive. As a minimally invasive and quantifiable biomarker, circulating cell-free mitochondrial DNA (ccf-mtDNA) in blood offers potential for objective assessment of mitochondrial stress in MDD. However, evidence linking regarding the association between ccf-mtDNA levels and MDD is limited and inconsistent.<h4>Methods</h4>We systematically searched eight databases, including PubMed, EMBASE, and major Chinese repositories. Thirteen studies with 1370 participants (837 individuals with MDD and 533 controls) were included per PRISMA guidelines. P-values were synthesized using the Lipták-Stouffer Z-score method. Sensitivity and fail-safe N analyses ass","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T14:50:30.505Z","creation":"2026-07-09T11:02:23.409Z"},"accession":"S-EPMC12923772","cross_references":{"pubmed":["41651814"],"doi":["10.1038/s41398-026-03865-2"]}}