{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu L"],"funding":["Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology)"],"pagination":["1899"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12923798"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Thermosensation is evolutionarily conserved for survival, yet the roles of glia in temperature coding and circuit dynamics remain poorly understood. Here, we identify C. elegans AMsh glia as dual-mode thermosensory hubs that autonomously detect temperature fluctuations by co-expressing the heat receptor GCY-28 (guanylate cyclase) and cold receptor GLR-3 (ionotropic glutamate receptor). Thermal changes induce spatiotemporal calcium dynamics in glia, driving GABA release to bidirectionally modulate neural circuits: enhancing AFD-mediated warmth detection through the excitatory receptor EXP-1 and suppressing ASH-dependent cold avoidance via the inhibitory receptor LGC-38. This GABAergic hub-and-spoke architecture regulates a broad range of thermal behaviors, including thermal avoidance, therm"],"journal":["Nature communications"],"pubmed_title":["A Glial Hub-and-Spoke Circuitry in C. elegans orchestrates bidirectional thermosensation."],"pmcid":["PMC12923798"],"funding_grant_id":["2021ZD0203303"],"pubmed_authors":["Hong H","Lei J","Li R","Zhou Y","Li Y","Li Z","Lv F","Zhu L","Zhang Y","Zhao G","Ma H","Guan MX","Gong J","Kang L","Qian M","Zou W"],"additional_accession":[]},"is_claimable":false,"name":"A Glial Hub-and-Spoke Circuitry in C. elegans orchestrates bidirectional thermosensation.","description":"Thermosensation is evolutionarily conserved for survival, yet the roles of glia in temperature coding and circuit dynamics remain poorly understood. Here, we identify C. elegans AMsh glia as dual-mode thermosensory hubs that autonomously detect temperature fluctuations by co-expressing the heat receptor GCY-28 (guanylate cyclase) and cold receptor GLR-3 (ionotropic glutamate receptor). Thermal changes induce spatiotemporal calcium dynamics in glia, driving GABA release to bidirectionally modulate neural circuits: enhancing AFD-mediated warmth detection through the excitatory receptor EXP-1 and suppressing ASH-dependent cold avoidance via the inhibitory receptor LGC-38. This GABAergic hub-and-spoke architecture regulates a broad range of thermal behaviors, including thermal avoidance, therm","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T17:46:47.845Z","creation":"2026-07-09T11:10:16.22Z"},"accession":"S-EPMC12923798","cross_references":{"pubmed":["41565681"],"doi":["10.1038/s41467-026-68766-w"]}}