biostudies-literatureUnknown7(2)Fleischer VThe choroid plexus (CP), a key regulator of cerebrospinal fluid production and immune cell trafficking, is increasingly recognized as a potential magnetic resonance imaging (MRI) biomarker in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) serves as a sensitive blood-based indicator of neuroaxonal injury. We investigate the prognostic value of CP volume and its longitudinal change for neurodegeneration, defined by sNfL levels and disability progression. In a prospective, multicenter, longitudinal study, 891 people with MS undergo high-resolution 3T MRI, sNfL measurement, and clinical assessment over 6 years; 434 meet criteria for inclusion. CP volume correlates with sNfL after adjustment for demographic, clinical, treatment, and imaging variables. In a 2-year MRI subcohort Cell reports. Medicine102609https://www.ebi.ac.uk/biostudies/studies/S-EPMC12923943biostudies-literatureChoroid plexus enlargement associates with serum neurofilament and predicts relapse-free progression in multiple sclerosis.PMC12923943Wiendl HSalmen AGold RLuessi FLukas CBittner SZipp FSchneider RProtopapa MMeuth SGGonzalez-Escamilla GSchraad MKlotz LGroppa SFleischer VBrummer THanuscheck NSteffen FfalseChoroid plexus enlargement associates with serum neurofilament and predicts relapse-free progression in multiple sclerosis.The choroid plexus (CP), a key regulator of cerebrospinal fluid production and immune cell trafficking, is increasingly recognized as a potential magnetic resonance imaging (MRI) biomarker in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) serves as a sensitive blood-based indicator of neuroaxonal injury. We investigate the prognostic value of CP volume and its longitudinal change for neurodegeneration, defined by sNfL levels and disability progression. In a prospective, multicenter, longitudinal study, 891 people with MS undergo high-resolution 3T MRI, sNfL measurement, and clinical assessment over 6 years; 434 meet criteria for inclusion. CP volume correlates with sNfL after adjustment for demographic, clinical, treatment, and imaging variables. In a 2-year MRI subcohort 2026-01-01T00:00:00Z2026 Feb2026-07-16T14:51:12.164Z2026-07-09T11:02:30.271ZS-EPMC129239434166692210.1016/j.xcrm.2026.102609