biostudies-literatureZhang ZNational Natural Science Foundation of China31https://www.ebi.ac.uk/biostudies/studies/S-EPMC12924263biostudies-literatureUnknown24(1)<h4>Background</h4>The relationship between kidney function and mortality in centenarians, particularly with respect to hormonal regulation, remains unclear. This study investigated the association between estimated glomerular filtration rate (eGFR) and all-cause mortality in female centenarians and explored the potential role of testosterone.<h4>Methods</h4>Within the China Hainan Centenarian Cohort Study, 701 female centenarians (median age: 102 years) were enrolled. eGFR was calculated using the CKD-EPI 2009 creatinine equation. Restricted cubic splines (RCSs) and multivariable Cox proportional hazards models were employed to assess nonlinear associations. Likelihood ratio tests were used to evaluate the interaction effect of testosterone.<h4>Results</h4>During a median follow-up of 31 Reproductive biology and endocrinology : RB&ETestosterone modifies U-Shaped association of eGFR with all-cause mortality in Chinese female centenarians: a prospective cohort study.PMC12924263No. 82270769Li HFeng ZLiu MWang BCheng XZhao YNiu YCai GZhang WWang QHe YZhang ZQu ZSun DChen YChen XfalseTestosterone modifies U-Shaped association of eGFR with all-cause mortality in Chinese female centenarians: a prospective cohort study.<h4>Background</h4>The relationship between kidney function and mortality in centenarians, particularly with respect to hormonal regulation, remains unclear. This study investigated the association between estimated glomerular filtration rate (eGFR) and all-cause mortality in female centenarians and explored the potential role of testosterone.<h4>Methods</h4>Within the China Hainan Centenarian Cohort Study, 701 female centenarians (median age: 102 years) were enrolled. eGFR was calculated using the CKD-EPI 2009 creatinine equation. Restricted cubic splines (RCSs) and multivariable Cox proportional hazards models were employed to assess nonlinear associations. Likelihood ratio tests were used to evaluate the interaction effect of testosterone.<h4>Results</h4>During a median follow-up of 31 2026-01-01T00:00:00Z2026 Jan2026-07-16T14:52:54.408Z2026-07-09T11:03:02.992ZS-EPMC129242634160664510.1186/s12958-026-01529-w