{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sadeghpour H"],"funding":["Shiraz University of Medical Sciences"],"pagination":["32"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12924469"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["Tyrosinase is a critical rate-limiting enzyme in the melanogenesis pathway. Consequently, its inhibition represents a rational therapeutic strategy for treating skin disorders associated with excessive melanin production. In the present study, a series of novel 3-hydroxypyridine-4-one derivatives (6a-i) were synthesized, and their chemical structures were confirmed using spectroscopic techniques. The inhibitory potency of these compounds against tyrosinase was predicted using quantitative structure-activity relationship (QSAR) analysis. QSAR modeling was conducted on twenty-four previously synthesized 3-hydroxypyridin-4-one derivatives with established anti-tyrosinase activity. The best-performing model was subsequently employed to predict the IC<sub>50</sub> values of the newly synthesize"],"journal":["BMC chemistry"],"pubmed_title":["Synthesis, QSAR analysis and molecular docking study of a new series of 3-hydroxypyridine-4-one derivatives as anti-tyrosinase agents."],"pmcid":["PMC12924469"],"funding_grant_id":["26571 and 25951"],"pubmed_authors":["Sadeghian S","Ghezeli ZK","Sadeghpour H","Razmi P","Emami L","Sabet R","Moradian A","Bahrampour A","Khoshneviszadeh M"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis, QSAR analysis and molecular docking study of a new series of 3-hydroxypyridine-4-one derivatives as anti-tyrosinase agents.","description":"Tyrosinase is a critical rate-limiting enzyme in the melanogenesis pathway. Consequently, its inhibition represents a rational therapeutic strategy for treating skin disorders associated with excessive melanin production. In the present study, a series of novel 3-hydroxypyridine-4-one derivatives (6a-i) were synthesized, and their chemical structures were confirmed using spectroscopic techniques. The inhibitory potency of these compounds against tyrosinase was predicted using quantitative structure-activity relationship (QSAR) analysis. QSAR modeling was conducted on twenty-four previously synthesized 3-hydroxypyridin-4-one derivatives with established anti-tyrosinase activity. The best-performing model was subsequently employed to predict the IC<sub>50</sub> values of the newly synthesize","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T15:13:12.793Z","creation":"2026-07-10T03:09:09.995Z"},"accession":"S-EPMC12924469","cross_references":{"pubmed":["41612407"],"doi":["10.1186/s13065-025-01709-6"]}}