{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu L"],"funding":["The Natural Science Foundation of Zhejiang Province","The National Natural Science Foundation of China"],"pagination":["115"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12924499"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>Localization of the epileptogenic zone (EZ) requires further refinement. We identified a unique ictal spectral structure, the \"harmonic pattern\" (H pattern), which potentially serves as a novel biomarker for localizing the EZ. This study aimed to analyze the clinical significance of the H pattern and to explore its underlying waveform features.<h4>Methods</h4>Seventy patients with drug-resistant focal epilepsy, undergoing stereo-EEG (SEEG) evaluation and surgery, were included. Time-frequency maps (TFM) were generated using Morlet wavelet transform analysis. The H pattern was defined as multiple equidistant, high-density bands with varying frequencies on TFM. The upper quartile was employed to confirm contacts expressing dominant H pattern (dH pattern). Bispectral analys"],"journal":["BMC medicine"],"pubmed_title":["Harmonic patterns embedded in ictal EEG signals in focal epilepsy: new insight into the epileptogenic zone."],"pmcid":["PMC12924499"],"funding_grant_id":["82171437","LD24H090003"],"pubmed_authors":["Zheng Z","Xiong K","Jiang H","Shen C","Huang K","Chen C","Yang D","Ding M","Liu X","Ye L","Zhu J","Chen Z","Zhang Y","Wang S","Hu L","Weiss S","Ye H","Wang Z","Wu Y","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Harmonic patterns embedded in ictal EEG signals in focal epilepsy: new insight into the epileptogenic zone.","description":"<h4>Background</h4>Localization of the epileptogenic zone (EZ) requires further refinement. We identified a unique ictal spectral structure, the \"harmonic pattern\" (H pattern), which potentially serves as a novel biomarker for localizing the EZ. This study aimed to analyze the clinical significance of the H pattern and to explore its underlying waveform features.<h4>Methods</h4>Seventy patients with drug-resistant focal epilepsy, undergoing stereo-EEG (SEEG) evaluation and surgery, were included. Time-frequency maps (TFM) were generated using Morlet wavelet transform analysis. The H pattern was defined as multiple equidistant, high-density bands with varying frequencies on TFM. The upper quartile was employed to confirm contacts expressing dominant H pattern (dH pattern). Bispectral analys","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T17:39:56.454Z","creation":"2026-07-09T11:08:27.378Z"},"accession":"S-EPMC12924499","cross_references":{"pubmed":["41606732"],"doi":["10.1186/s12916-026-04665-7"]}}