{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Tien D"],"funding":["NIDDK NIH HHS","NIAID NIH HHS"],"pubmed_abstract":["Background
People with HIV (PWH) have experienced excess weight gain on tenofovir, lamivudine, and dolutegravir (TLD). The contribution of lifestyle behavior to this weight gain is poorly understood.Methods
The Population Effectiveness of Dolutegravir Implementation in sub-Saharan Africa (DISCO Study) was a prospective observational cohort study that followed participants in KwaZulu-Natal, South Africa, transitioning to TLD. Our primary outcome of interest was clinically significant weight gain, defined as ≥10% increase from baseline to 48 weeks. Primary exposures of interest were (1) fruit intake (servings/week), (2) vegetable intake (servings/week), (3) fast food intake frequency, (4) fried food intake frequency, (5) sugar-sweetened beverage (SSB) intake frequency, and (6"],"journal":["Journal of acquired immune deficiency syndromes (1999)"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12924645"],"repository":["biostudies-literature"],"pubmed_title":["Dolutegravir-based therapy, diet, physical activity and weight gain: a 48-week prospective cohort in South Africa."],"pmcid":["PMC12924645"],"funding_grant_id":["K23 AI143470","K23 DK125162","P30 AI050409"],"pubmed_authors":["Pillay D","Chandiwana N","Manne-Goehler J","Hedt-Gauthier B","Chen G","Siedner MJ","Tien D","Shazi G","Gupta RK","Moosa MS","McCluskey SM","Marconi VC","Venter WDF","Mabweazara S"],"additional_accession":[]},"is_claimable":false,"name":"Dolutegravir-based therapy, diet, physical activity and weight gain: a 48-week prospective cohort in South Africa.","description":"Background
People with HIV (PWH) have experienced excess weight gain on tenofovir, lamivudine, and dolutegravir (TLD). The contribution of lifestyle behavior to this weight gain is poorly understood.Methods
The Population Effectiveness of Dolutegravir Implementation in sub-Saharan Africa (DISCO Study) was a prospective observational cohort study that followed participants in KwaZulu-Natal, South Africa, transitioning to TLD. Our primary outcome of interest was clinically significant weight gain, defined as ≥10% increase from baseline to 48 weeks. Primary exposures of interest were (1) fruit intake (servings/week), (2) vegetable intake (servings/week), (3) fast food intake frequency, (4) fried food intake frequency, (5) sugar-sweetened beverage (SSB) intake frequency, and (6","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-16T14:46:20.103Z","creation":"2026-07-09T11:01:08.519Z"},"accession":"S-EPMC12924645","cross_references":{"pubmed":["41329528"],"doi":["10.1097/qai.0000000000003812","10.1097/QAI.0000000000003812"]}}