biostudies-literatureUnknownTien DNIDDK NIH HHSNIAID NIH HHS<h4>Background</h4>People with HIV (PWH) have experienced excess weight gain on tenofovir, lamivudine, and dolutegravir (TLD). The contribution of lifestyle behavior to this weight gain is poorly understood.<h4>Methods</h4>The Population Effectiveness of Dolutegravir Implementation in sub-Saharan Africa (DISCO Study) was a prospective observational cohort study that followed participants in KwaZulu-Natal, South Africa, transitioning to TLD. Our primary outcome of interest was clinically significant weight gain, defined as ≥10% increase from baseline to 48 weeks. Primary exposures of interest were (1) fruit intake (servings/week), (2) vegetable intake (servings/week), (3) fast food intake frequency, (4) fried food intake frequency, (5) sugar-sweetened beverage (SSB) intake frequency, and (6Journal of acquired immune deficiency syndromes (1999)https://www.ebi.ac.uk/biostudies/studies/S-EPMC12924645biostudies-literatureDolutegravir-based therapy, diet, physical activity and weight gain: a 48-week prospective cohort in South Africa.PMC12924645K23 AI143470K23 DK125162P30 AI050409Pillay DChandiwana NManne-Goehler JHedt-Gauthier BChen GSiedner MJTien DShazi GGupta RKMoosa MSMcCluskey SMMarconi VCVenter WDFMabweazara SfalseDolutegravir-based therapy, diet, physical activity and weight gain: a 48-week prospective cohort in South Africa.<h4>Background</h4>People with HIV (PWH) have experienced excess weight gain on tenofovir, lamivudine, and dolutegravir (TLD). The contribution of lifestyle behavior to this weight gain is poorly understood.<h4>Methods</h4>The Population Effectiveness of Dolutegravir Implementation in sub-Saharan Africa (DISCO Study) was a prospective observational cohort study that followed participants in KwaZulu-Natal, South Africa, transitioning to TLD. Our primary outcome of interest was clinically significant weight gain, defined as ≥10% increase from baseline to 48 weeks. Primary exposures of interest were (1) fruit intake (servings/week), (2) vegetable intake (servings/week), (3) fast food intake frequency, (4) fried food intake frequency, (5) sugar-sweetened beverage (SSB) intake frequency, and (62025-01-01T00:00:00Z2025 Dec2026-07-16T14:46:20.103Z2026-07-09T11:01:08.519ZS-EPMC129246454132952810.1097/qai.000000000000381210.1097/QAI.0000000000003812