{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chu X"],"funding":["NCI NIH HHS"],"pagination":["e70772"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12924702"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["98(1)"],"pubmed_abstract":["Kaposi sarcoma (KS) is an endothelial cancer caused by the Kaposi sarcoma-associated herpesvirus (KSHV), and it remains one of the most frequently diagnosed and fatal cancers in sub-Saharan Africa. Achieving timely and accurate diagnosis for KS is a critical challenge in sub-Saharan Africa, where access to histopathology is limited and clinical diagnosis is often erroneous. Previously, a point-of-care device was developed to quantify KSHV DNA and demonstrated promising performance, achieving 97% sensitivity and 92% specificity at a 26-min threshold in a training set of patients from several Ugandan clinics. Herein, 421 skin biopsies from a different, test set of patients identified later in calendar time at the same clinical sites were examined using the same methodology. Using the previou"],"journal":["Journal of medical virology"],"pubmed_title":["Loop-Mediated Isothermal Amplification Enables Reliable Kaposi Sarcoma Diagnosis Across Time and Sites in East Africa."],"pmcid":["PMC12924702"],"funding_grant_id":["U01 CA269199"],"pubmed_authors":["Semeere A","Boza JM","Maurer T","Muwando H","Chu X","Wenger M","Cesarman E","Ayanga R","Manning JC","Martin J","Lukande R","Erickson D","Mcgaskey M"],"additional_accession":[]},"is_claimable":false,"name":"Loop-Mediated Isothermal Amplification Enables Reliable Kaposi Sarcoma Diagnosis Across Time and Sites in East Africa.","description":"Kaposi sarcoma (KS) is an endothelial cancer caused by the Kaposi sarcoma-associated herpesvirus (KSHV), and it remains one of the most frequently diagnosed and fatal cancers in sub-Saharan Africa. Achieving timely and accurate diagnosis for KS is a critical challenge in sub-Saharan Africa, where access to histopathology is limited and clinical diagnosis is often erroneous. Previously, a point-of-care device was developed to quantify KSHV DNA and demonstrated promising performance, achieving 97% sensitivity and 92% specificity at a 26-min threshold in a training set of patients from several Ugandan clinics. Herein, 421 skin biopsies from a different, test set of patients identified later in calendar time at the same clinical sites were examined using the same methodology. Using the previou","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T14:44:04.649Z","creation":"2026-07-09T11:00:29.272Z"},"accession":"S-EPMC12924702","cross_references":{"pubmed":["41439791"],"doi":["10.1002/jmv.70772"]}}