{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Su Y"],"funding":["National Natural Science Foundation of China","China Postdoctoral Science Foundation"],"pagination":["102330"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12924745"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["105"],"pubmed_abstract":["Aims
Human adipose tissue is central to obesity-associated metabolic dysfunction. ANKRD53 is a human-specific, adipocyte-enriched ankyrin repeat scaffold protein with largely unknown function. We investigated its role in human adipocyte metabolism and the underlying mechanism.Methods
RNA-seq analysis of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) from 236 individuals quantified ANKRD53 expression and its association with metabolic traits. In human primary adipocytes, we assessed lipolysis (free fatty acid and glycerol release) and mitochondrial respiration (oxygen consumption rate) after ANKRD53 overexpression or knockdown. An AAV was used to overexpress ANKRD53 in mouse inguinal white adipose tissue (iWAT). Protein interactors were identified by imm"],"journal":["Molecular metabolism"],"pubmed_title":["ANKRD53 is downregulated in human obesity and coordinates lipolysis with mitochondrial oxidative metabolism in adipocytes."],"pmcid":["PMC12924745"],"funding_grant_id":["2024M762052","821.70889","82400999"],"pubmed_authors":["Li X","Yang Y","Lu X","Cai J","Ma X","Su Y","Wang Y","Ye Y","Liu T","Sun J","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"ANKRD53 is downregulated in human obesity and coordinates lipolysis with mitochondrial oxidative metabolism in adipocytes.","description":"Aims
Human adipose tissue is central to obesity-associated metabolic dysfunction. ANKRD53 is a human-specific, adipocyte-enriched ankyrin repeat scaffold protein with largely unknown function. We investigated its role in human adipocyte metabolism and the underlying mechanism.Methods
RNA-seq analysis of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) from 236 individuals quantified ANKRD53 expression and its association with metabolic traits. In human primary adipocytes, we assessed lipolysis (free fatty acid and glycerol release) and mitochondrial respiration (oxygen consumption rate) after ANKRD53 overexpression or knockdown. An AAV was used to overexpress ANKRD53 in mouse inguinal white adipose tissue (iWAT). Protein interactors were identified by imm","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T18:46:42.895Z","creation":"2026-07-12T03:07:27.148Z"},"accession":"S-EPMC12924745","cross_references":{"pubmed":["41654016"],"doi":["10.1016/j.molmet.2026.102330"]}}