biostudies-literatureUnknown19Mesonero F<h4>Background</h4>Inflammatory pouch disorders can be refractory to conventional therapy. Evidence on biological therapy from large cohorts is scarce.<h4>Objective</h4>To explore the use and effectiveness of biological therapy for inflammatory pouch disorders.<h4>Design</h4>A retrospective and multicentre study.<h4>Methods</h4>We included patients diagnosed with pouchitis, Crohn's Disease of the Pouch (CDP) or cuffitis and treated with biological therapy. Effectiveness was evaluated at 12 months based on normalisation of stool frequency, absence of pain, faecal urgency or fistula discharge (clinical remission), or as any improvement in these symptoms (clinical response). We also compared the effectiveness of a second biologic after anti-tumour necrosis factor (anti-TNF) failure using descTherapeutic advances in gastroenterology17562848261422373https://www.ebi.ac.uk/biostudies/studies/S-EPMC12925033biostudies-literatureBiological therapies for inflammatory pouch disorders: insights and outcomes from the RESERVO study of GETECCU.PMC12925033Vicuna MFerreiro-Iglesias RBastida GFajardo ILopez-Sanroman ALeo-Carnerero ENajera RHernandez-Camba AFernandez-Clotet AFerrer CSTorrealba LCastano AHermida BSanchez-Guillen LGutierrez ABenitez JMRodriguez-Grau MCPiqueras MCaballol BBaston-Rey IAlbillos ABouhmidi ASuris GSobrino AGonzalez-Partida ICasis BLamuela LJPajares RMontoro-Huguet MALopez-Garcia ASaiz-Chumillas RMZabana YRubin de Celix CCalafat MElosua AMesonero FCaballero-Mateos AGarcia MJTejido CBaltar RHuguet JMBarreiro-de Acosta MBrunet-Mas ENunez AJimenez IGarcia-Morales NRamos LMiranda-Bautista JRodriguez-Lago IBertoletti FfalseBiological therapies for inflammatory pouch disorders: insights and outcomes from the RESERVO study of GETECCU.<h4>Background</h4>Inflammatory pouch disorders can be refractory to conventional therapy. Evidence on biological therapy from large cohorts is scarce.<h4>Objective</h4>To explore the use and effectiveness of biological therapy for inflammatory pouch disorders.<h4>Design</h4>A retrospective and multicentre study.<h4>Methods</h4>We included patients diagnosed with pouchitis, Crohn's Disease of the Pouch (CDP) or cuffitis and treated with biological therapy. Effectiveness was evaluated at 12 months based on normalisation of stool frequency, absence of pain, faecal urgency or fistula discharge (clinical remission), or as any improvement in these symptoms (clinical response). We also compared the effectiveness of a second biologic after anti-tumour necrosis factor (anti-TNF) failure using desc2026-01-01T00:00:00Z20262026-07-16T18:46:45.642Z2026-07-12T03:07:31.565ZS-EPMC129250334173233010.1177/17562848261422373