{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jelleschitz S"],"funding":["Austrian Science Fund FWF","Österreichische Nationalstiftung für Forschung, Technologie und Entwicklung","Christian Doppler Forschungsgesellschaft"],"pagination":["104069"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12925199"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["91"],"pubmed_abstract":["Senescent dermal fibroblasts accumulate and secrete chemically reactive lipids that are components of the senescence-associated secretory phenotype (SASP). These lipids, including 4-hydroxynonenal (HNE) and reactive oxidized phospholipids (OxPL), covalently bind to and modify proteins via Schiff base formation or Michael adduction. Our study examined lipid-induced collagen modifications and their impact on skin cells to evaluate the long-term consequences of senescent cells on the tissue microenvironment. Using mass spectrometry and biochemical analyses, we identified both high and low molecular-weight modifications to collagen types I, II and IV. Collagen modified by HNE reduced fibroblast proliferation and induced stress responses. In contrast, collagen modified by OxPL provoked inflamma"],"journal":["Redox biology"],"pubmed_title":["Modification of the dermal matrix by senescence associated lipids and its functional consequence."],"pmcid":["PMC12925199"],"funding_grant_id":["I-5627"],"pubmed_authors":["Mildner M","Narzt MS","Nagelreiter IM","Fedorova M","Jelleschitz S","Bauer C","Tessier A","Schirato M","Sandgren Fors A","Ni Z","Gendronneau G","Kremslehner C","Ben Khalifa Y","Stiegler A","Freystatter C","Marcato F","Andre N","Oskolkova O","Salek M","Gruber F"],"additional_accession":[]},"is_claimable":false,"name":"Modification of the dermal matrix by senescence associated lipids and its functional consequence.","description":"Senescent dermal fibroblasts accumulate and secrete chemically reactive lipids that are components of the senescence-associated secretory phenotype (SASP). These lipids, including 4-hydroxynonenal (HNE) and reactive oxidized phospholipids (OxPL), covalently bind to and modify proteins via Schiff base formation or Michael adduction. Our study examined lipid-induced collagen modifications and their impact on skin cells to evaluate the long-term consequences of senescent cells on the tissue microenvironment. Using mass spectrometry and biochemical analyses, we identified both high and low molecular-weight modifications to collagen types I, II and IV. Collagen modified by HNE reduced fibroblast proliferation and induced stress responses. In contrast, collagen modified by OxPL provoked inflamma","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-10T03:22:46.237Z","creation":"2026-07-10T03:10:20.593Z"},"accession":"S-EPMC12925199","cross_references":{"pubmed":["41690117"],"doi":["10.1016/j.redox.2026.104069"]}}