{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Eerden SA"],"funding":["Novo Nordisk Foundation","Horizon Europe","H2020 Marie Skłodowska-Curie Actions","Netherlands Organization for Applied Scientific Research"],"pagination":["100350"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12925313"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["Although biofilms are widespread in nature, the ecological roles and compositional diversity of the extracellular polymeric substances (EPS) forming these structures remain poorly understood. Here, we apply a bottom-up genomic approach by investigating the biosynthetic potential for glycan precursors in the genus \"<i>Candidatus</i> Accumulibacter\", with a focus on assessing the intra-genus variability. Within a curated set of 61 \"<i>Ca.</i> Accumulibacter\" MAGs, our analysis revealed a dichotomy in glycan precursors between a conserved core group of 9 nucleotide-sugars and a variable accessory set of 12 nucleotide-sugars, out of 50 nucleotide-sugars tested. The core nucleotide-sugars in \"<i>Ca</i>. Accumulibacter\" are related to nucleotide-sugars also found to be widely distributed across "],"journal":["Biofilm"],"pubmed_title":["Phylogenetic analysis reveals diversity in glycan biosynthesis in \"&lt;i&gt;Candidatus&lt;/i&gt; Accumulibacter\"."],"pmcid":["PMC12925313"],"funding_grant_id":["NNF 22OC0071498","101068900"],"pubmed_authors":["Abeel T","Eerden SA","van Loosdrecht MCM","Roy S"],"additional_accession":[]},"is_claimable":false,"name":"Phylogenetic analysis reveals diversity in glycan biosynthesis in \"&lt;i&gt;Candidatus&lt;/i&gt; Accumulibacter\".","description":"Although biofilms are widespread in nature, the ecological roles and compositional diversity of the extracellular polymeric substances (EPS) forming these structures remain poorly understood. Here, we apply a bottom-up genomic approach by investigating the biosynthetic potential for glycan precursors in the genus \"<i>Candidatus</i> Accumulibacter\", with a focus on assessing the intra-genus variability. Within a curated set of 61 \"<i>Ca.</i> Accumulibacter\" MAGs, our analysis revealed a dichotomy in glycan precursors between a conserved core group of 9 nucleotide-sugars and a variable accessory set of 12 nucleotide-sugars, out of 50 nucleotide-sugars tested. The core nucleotide-sugars in \"<i>Ca</i>. Accumulibacter\" are related to nucleotide-sugars also found to be widely distributed across ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jun","modification":"2026-07-12T03:16:16.135Z","creation":"2026-07-12T03:08:01.613Z"},"accession":"S-EPMC12925313","cross_references":{"pubmed":["41732174"],"doi":["10.1016/j.bioflm.2026.100350"]}}