{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mamorita S"],"funding":["Innovative Drug Discovery and Life Science Research from AMED","JSPS KAKENHI","Nipponham Foundation for the Future of Food, KOSÉ Cosmetology Research Foundation, Hoyu Science Foundation, Naito Foundation, and Takeda Science Foundation"],"pagination":["e70152"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12925385"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["56(2)"],"pubmed_abstract":["Allergic diseases are a global health concern, and new molecular insights and therapeutic agents are necessary to support future research and interventions. Mast cells (MCs) play a crucial role in allergic reactions, in which antigen (Ag) cross-linking of high-affinity receptors (FcεRI) activates signaling pathways, leading to the release of various types of inflammatory mediators. We developed a chemical library screening system using RBL-2H3 cells, a widely used MC model, to identify anti-allergic agents. This method revealed that lomitapide, a microsomal triglyceride transfer protein (MTTP) inhibitor, is a novel MC regulatory agent. Furthermore, lomitapide was found to inhibit MC degranulation by altering MC plasma membrane dynamics, specifically by preventing endocytosis of plasma memb"],"journal":["European journal of immunology"],"pubmed_title":["Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent Through Chemical Library Screening."],"pmcid":["PMC12925385"],"funding_grant_id":["JP23ama121053","19H03369","16H05082"],"pubmed_authors":["Suzuki R","Mamorita S","Nagata Y","Furukawa A"],"additional_accession":[]},"is_claimable":false,"name":"Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent Through Chemical Library Screening.","description":"Allergic diseases are a global health concern, and new molecular insights and therapeutic agents are necessary to support future research and interventions. Mast cells (MCs) play a crucial role in allergic reactions, in which antigen (Ag) cross-linking of high-affinity receptors (FcεRI) activates signaling pathways, leading to the release of various types of inflammatory mediators. We developed a chemical library screening system using RBL-2H3 cells, a widely used MC model, to identify anti-allergic agents. This method revealed that lomitapide, a microsomal triglyceride transfer protein (MTTP) inhibitor, is a novel MC regulatory agent. Furthermore, lomitapide was found to inhibit MC degranulation by altering MC plasma membrane dynamics, specifically by preventing endocytosis of plasma memb","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T15:18:41.24Z","creation":"2026-07-11T03:07:57.449Z"},"accession":"S-EPMC12925385","cross_references":{"pubmed":["41723726"],"doi":["10.1002/eji.70152"]}}