{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["70(4)"],"submitter":["Brehmer-Henkel S"],"funding":["AQUANOVA AG"],"pubmed_abstract":["Xanthohumol is a prenylated chalcone, which is mainly found in hops. Experimental studies show a variety of cardioprotective effects for xanthohumol, but so far there are only a few controlled studies on the bioavailability and efficacy of xanthohumol in humans. In a randomized crossover bioavailability trial, the plasma kinetics of 86 mg and 172 mg each of micellar or native xanthohumol were investigated. Blood samples were obtained at fasting (t<sub>0</sub>), regularly until 9 h and 24 h after oral xanthohumol bolus administration and the plasma concentrations of xanthohumol, xanthohumol glucuronide, and xanthohumol sulfate were analyzed. Micellation increased the area under the plasma concentration-time curve (AUC) (p < 0.001) and maximum plasma concentration (p <0.001). Both formulatio"],"journal":["Molecular nutrition & food research"],"pagination":["e70413"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12925386"],"repository":["biostudies-literature"],"pubmed_title":["The Bioavailability of Xanthohumol in Humans and the Influence of Formulation and Dose: Randomized Controlled Trial Data."],"pmcid":["PMC12925386"],"pubmed_authors":["Coenen M","Nemeth R","Maris R","Stoffel-Wagner B","Sus N","Eickeler M","Kopp C","Frank J","Brehmer-Henkel S","Diekmann C","Egert S"],"additional_accession":[]},"is_claimable":false,"name":"The Bioavailability of Xanthohumol in Humans and the Influence of Formulation and Dose: Randomized Controlled Trial Data.","description":"Xanthohumol is a prenylated chalcone, which is mainly found in hops. Experimental studies show a variety of cardioprotective effects for xanthohumol, but so far there are only a few controlled studies on the bioavailability and efficacy of xanthohumol in humans. In a randomized crossover bioavailability trial, the plasma kinetics of 86 mg and 172 mg each of micellar or native xanthohumol were investigated. Blood samples were obtained at fasting (t<sub>0</sub>), regularly until 9 h and 24 h after oral xanthohumol bolus administration and the plasma concentrations of xanthohumol, xanthohumol glucuronide, and xanthohumol sulfate were analyzed. Micellation increased the area under the plasma concentration-time curve (AUC) (p < 0.001) and maximum plasma concentration (p <0.001). Both formulatio","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T18:48:23.439Z","creation":"2026-07-12T03:08:30.736Z"},"accession":"S-EPMC12925386","cross_references":{"pubmed":["41723719"],"doi":["10.1002/mnfr.70413"]}}