biostudies-literatureUnknown70(4)Brehmer-Henkel SAQUANOVA AGXanthohumol is a prenylated chalcone, which is mainly found in hops. Experimental studies show a variety of cardioprotective effects for xanthohumol, but so far there are only a few controlled studies on the bioavailability and efficacy of xanthohumol in humans. In a randomized crossover bioavailability trial, the plasma kinetics of 86 mg and 172 mg each of micellar or native xanthohumol were investigated. Blood samples were obtained at fasting (t₀), regularly until 9 h and 24 h after oral xanthohumol bolus administration and the plasma concentrations of xanthohumol, xanthohumol glucuronide, and xanthohumol sulfate were analyzed. Micellation increased the area under the plasma concentration-time curve (AUC) (p < 0.001) and maximum plasma concentration (p <0.001). Both formulatioMolecular nutrition & food researche70413https://www.ebi.ac.uk/biostudies/studies/S-EPMC12925386biostudies-literatureThe Bioavailability of Xanthohumol in Humans and the Influence of Formulation and Dose: Randomized Controlled Trial Data.PMC12925386Coenen MNemeth RMaris RStoffel-Wagner BSus NEickeler MKopp CFrank JBrehmer-Henkel SDiekmann CEgert SfalseThe Bioavailability of Xanthohumol in Humans and the Influence of Formulation and Dose: Randomized Controlled Trial Data.Xanthohumol is a prenylated chalcone, which is mainly found in hops. Experimental studies show a variety of cardioprotective effects for xanthohumol, but so far there are only a few controlled studies on the bioavailability and efficacy of xanthohumol in humans. In a randomized crossover bioavailability trial, the plasma kinetics of 86 mg and 172 mg each of micellar or native xanthohumol were investigated. Blood samples were obtained at fasting (t₀), regularly until 9 h and 24 h after oral xanthohumol bolus administration and the plasma concentrations of xanthohumol, xanthohumol glucuronide, and xanthohumol sulfate were analyzed. Micellation increased the area under the plasma concentration-time curve (AUC) (p < 0.001) and maximum plasma concentration (p <0.001). Both formulatio2026-01-01T00:00:00Z2026 Feb2026-07-16T18:48:23.439Z2026-07-12T03:08:30.736ZS-EPMC129253864172371910.1002/mnfr.70413