{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Estarellas C"],"funding":["European Social Fund Plus","Ministerio de Ciencia e Innovación","Agencia Estatal de Investigacion"],"pagination":["114878"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12925530"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(3)"],"pubmed_abstract":["In the dentate gyrus (DG), tight inhibitory control confines the activity of granule cells (GCs)-a key characteristic for its proposed role as a pattern separator. Nonetheless, a conundrum arises concerning the balance between sparseness of GC firing and the activity level needed for efficient transmission downstream to CA3. Using <i>in vivo</i> electrophysiology, pharmacogenetics, and computational modeling, we identified a synaptic plasticity mechanism that decouples excitation from inhibition, enhancing information encoding and transmission without compromising pattern separation. Long-term synaptic potentiation of the perforant pathway, in addition to strengthening the glutamatergic synapses into GCs, depressed feedforward perisomatic inhibition. Computational modeling revealed a funct"],"journal":["iScience"],"pubmed_title":["Synaptic plasticity in the perforant pathway drives inhibitory reorganization enhancing dentate gyrus functionality."],"pmcid":["PMC12925530"],"funding_grant_id":["MICIU/AEI/10.13039/501100011033","PID2021-128158NB-C21","PID2021-128158NB-C22","PID2024-162400OB-C22","PID2024-162400OB-C21","FPI/1900/2016"],"pubmed_authors":["Perez-Cervera L","Canals S","Lopez-Madrona VJ","Perez-Montoyo E","Mirasso CR","Carames JM","Estarellas C","Garcia-Hernandez R","Alvarez-Salvado E"],"additional_accession":[]},"is_claimable":false,"name":"Synaptic plasticity in the perforant pathway drives inhibitory reorganization enhancing dentate gyrus functionality.","description":"In the dentate gyrus (DG), tight inhibitory control confines the activity of granule cells (GCs)-a key characteristic for its proposed role as a pattern separator. Nonetheless, a conundrum arises concerning the balance between sparseness of GC firing and the activity level needed for efficient transmission downstream to CA3. Using <i>in vivo</i> electrophysiology, pharmacogenetics, and computational modeling, we identified a synaptic plasticity mechanism that decouples excitation from inhibition, enhancing information encoding and transmission without compromising pattern separation. Long-term synaptic potentiation of the perforant pathway, in addition to strengthening the glutamatergic synapses into GCs, depressed feedforward perisomatic inhibition. Computational modeling revealed a funct","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Mar","modification":"2026-07-16T18:47:46.719Z","creation":"2026-07-12T03:07:52.067Z"},"accession":"S-EPMC12925530","cross_references":{"pubmed":["41732253"],"doi":["10.1016/j.isci.2026.114878"]}}