{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liang M"],"funding":["Xinjiang Production and Construction Corps","National Natural Science Foundation of China"],"pagination":["100981"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12925546"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["67(2)"],"pubmed_abstract":["In recent studies, acute physiological stress has been shown to enhance liver gluconeogenesis by activating β3-adrenergic receptor (ADRB3)-dependent interleukin-6 (IL-6) production in brown adipocytes, effectively fueling \"fight or flight\" responses. However, the specific molecular mechanism of this IL-6 production in an ADRB3-dependent manner is not fully understood. ADRB3 regulates multiple metabolic programs in adipose tissue, including thermogenesis, lipolysis, and glucose uptake, by activating cAMP-PKA-CREB signaling. Our previous studies revealed that the transcription factor Krüppel-like factor 7 (KLF7) transcriptionally induces IL-6 expression in white adipocytes. Using Klf7-adipocyte knockout mice, we showed that Klf7 is also required for ADRB3-induced IL-6 production during stres"],"journal":["Journal of lipid research"],"pubmed_title":["KLF7 induced ADRB3-dependent IL-6 production in brown adipocytes during stress."],"pmcid":["PMC12925546"],"funding_grant_id":["2022ZD083","82260162","2022AB022","2023ZD037","62025102","2023AB057","82160156","2022ZD001"],"pubmed_authors":["Xu L","Zhang J","Wang C","Zhang H","Liu Q","Chu X","Zhang M","Hou Y","Wang J","Cui Q","Li W","Yuan F","Zhao M","Xie J","Liang M","Su Y"],"additional_accession":[]},"is_claimable":false,"name":"KLF7 induced ADRB3-dependent IL-6 production in brown adipocytes during stress.","description":"In recent studies, acute physiological stress has been shown to enhance liver gluconeogenesis by activating β3-adrenergic receptor (ADRB3)-dependent interleukin-6 (IL-6) production in brown adipocytes, effectively fueling \"fight or flight\" responses. However, the specific molecular mechanism of this IL-6 production in an ADRB3-dependent manner is not fully understood. ADRB3 regulates multiple metabolic programs in adipose tissue, including thermogenesis, lipolysis, and glucose uptake, by activating cAMP-PKA-CREB signaling. Our previous studies revealed that the transcription factor Krüppel-like factor 7 (KLF7) transcriptionally induces IL-6 expression in white adipocytes. Using Klf7-adipocyte knockout mice, we showed that Klf7 is also required for ADRB3-induced IL-6 production during stres","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-12T03:16:20.435Z","creation":"2026-07-12T03:08:03.535Z"},"accession":"S-EPMC12925546","cross_references":{"pubmed":["41565113"],"doi":["10.1016/j.jlr.2026.100981"]}}