biostudies-literatureLiang MXinjiang Production and Construction CorpsNational Natural Science Foundation of China100981https://www.ebi.ac.uk/biostudies/studies/S-EPMC12925546biostudies-literatureUnknown67(2)In recent studies, acute physiological stress has been shown to enhance liver gluconeogenesis by activating β3-adrenergic receptor (ADRB3)-dependent interleukin-6 (IL-6) production in brown adipocytes, effectively fueling "fight or flight" responses. However, the specific molecular mechanism of this IL-6 production in an ADRB3-dependent manner is not fully understood. ADRB3 regulates multiple metabolic programs in adipose tissue, including thermogenesis, lipolysis, and glucose uptake, by activating cAMP-PKA-CREB signaling. Our previous studies revealed that the transcription factor Krüppel-like factor 7 (KLF7) transcriptionally induces IL-6 expression in white adipocytes. Using Klf7-adipocyte knockout mice, we showed that Klf7 is also required for ADRB3-induced IL-6 production during stresJournal of lipid researchKLF7 induced ADRB3-dependent IL-6 production in brown adipocytes during stress.PMC129255462022ZD083822601622022AB0222023ZD037620251022023AB057821601562022ZD001Xu LZhang JWang CZhang HLiu QChu XZhang MHou YWang JCui QLi WYuan FZhao MXie JLiang MSu YfalseKLF7 induced ADRB3-dependent IL-6 production in brown adipocytes during stress.In recent studies, acute physiological stress has been shown to enhance liver gluconeogenesis by activating β3-adrenergic receptor (ADRB3)-dependent interleukin-6 (IL-6) production in brown adipocytes, effectively fueling "fight or flight" responses. However, the specific molecular mechanism of this IL-6 production in an ADRB3-dependent manner is not fully understood. ADRB3 regulates multiple metabolic programs in adipose tissue, including thermogenesis, lipolysis, and glucose uptake, by activating cAMP-PKA-CREB signaling. Our previous studies revealed that the transcription factor Krüppel-like factor 7 (KLF7) transcriptionally induces IL-6 expression in white adipocytes. Using Klf7-adipocyte knockout mice, we showed that Klf7 is also required for ADRB3-induced IL-6 production during stres2026-01-01T00:00:00Z2026 Jan2026-07-12T03:16:20.435Z2026-07-12T03:08:03.535ZS-EPMC129255464156511310.1016/j.jlr.2026.100981