{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Watling CZ"],"funding":["Intramural NIH HHS"],"pubmed_abstract":["<h4>Background</h4>Per- and polyfluoroalkyl substances (PFAS) have been associated with numerous deleterious health outcomes including liver damage. However, whether exposure to PFAS is associated with liver cancer risk remains unclear.<h4>Methods</h4>We conducted a matched nested case-control study among 12 prospective cohort studies located in the United States. Pre-diagnostic PFAS, namely perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS), were measured from blood samples among 853 individuals who developed liver cancer and 853 matched control participants. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable-adjusted conditional logistic regression for liver cancer risk by study-specific quartiles of concent"],"journal":["Environmental health perspectives"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12925619"],"repository":["biostudies-literature"],"pubmed_title":["Circulating per- and polyfluoroalkyl substances and liver cancer risk: a nested case-control analysis of individual participant data from 12 prospective cohorts."],"pmcid":["PMC12925619"],"funding_grant_id":["Z01 CP010158"],"pubmed_authors":["Um CY","Huang WY","Sesso HD","Wactawski-Wende J","McGlynn KA","Wu F","Palmer JR","Barnett MJ","Petrick JL","Visvanathan K","Rosenberg L","Chen Y","Watling CZ","Graubard BI","Shrubsole M","Willett W","Buring JE","Barupal D","Purdue MP","Zheng W","Eliassen AH","Mucci LA","Tinker L","Triplette M","Lee IM","Hofmann J","Campbell PT","Zhang X","Koshiol J","Kang JH","Gaziano M","Neuhouser ML","Newton CC","Moore SC"],"additional_accession":[]},"is_claimable":false,"name":"Circulating per- and polyfluoroalkyl substances and liver cancer risk: a nested case-control analysis of individual participant data from 12 prospective cohorts.","description":"<h4>Background</h4>Per- and polyfluoroalkyl substances (PFAS) have been associated with numerous deleterious health outcomes including liver damage. However, whether exposure to PFAS is associated with liver cancer risk remains unclear.<h4>Methods</h4>We conducted a matched nested case-control study among 12 prospective cohort studies located in the United States. Pre-diagnostic PFAS, namely perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS), were measured from blood samples among 853 individuals who developed liver cancer and 853 matched control participants. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable-adjusted conditional logistic regression for liver cancer risk by study-specific quartiles of concent","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-07-16T15:09:16.554Z","creation":"2026-07-09T11:03:02.518Z"},"accession":"S-EPMC12925619","cross_references":{"pubmed":["40397817"],"doi":["10.1289/ehp16980","10.1289/EHP16980"]}}