biostudies-literatureSakr SMAbbott LaboratoriesNIH HHS450-459https://www.ebi.ac.uk/biostudies/studies/S-EPMC12925993biostudies-literatureUnknown49(3)<h4>Objective</h4>Type 2 diabetes (T2D) is a significant risk factor for adverse outcomes in coronary heart disease (CHD). We investigated whether inflammation and immune dysregulation, measured using soluble urokinase plasminogen activator receptor (suPAR) and high-sensitivity C-reactive protein (hs-CRP) levels, mediate this risk.<h4>Research design and methods</h4>Patients with and without CHD enrolled in the Emory Cardiovascular Biobank had suPAR (ViroGates, Denmark) and hs-CRP levels measured and were followed for 1) cardiovascular death, 2) a composite of incident myocardial infarction and cardiovascular death, and 3) all-cause death. Fine and Gray or Cox proportional hazards models adjusted for demographic, clinical, and treatment variables were used. Regression-based causal mediatioDiabetes careSoluble Urokinase Plasminogen Activator Receptor (suPAR) Mediates the Impact of Diabetes on Adverse Outcomes in Coronary Artery Disease.PMC129259933R01HL157311-03S1P01HL154996-01A15T32 HL130025P30DK111024-07S2R01HL166004-015R01HL158141-0431R01HL166004-01R33HL138657-05Lodhi REldaidamouni AAAhmed THuang JSakr SMPasquel FJMedina-Inojosa JQuyyumi AAYadalam AKAli MKDesai SHarris KAYeboah RHaroun NRazavi ACOwais MKo YAMohan VTandon NAl Kasem MLiu CNarayan KMVHartsfield JDfalseSoluble Urokinase Plasminogen Activator Receptor (suPAR) Mediates the Impact of Diabetes on Adverse Outcomes in Coronary Artery Disease.<h4>Objective</h4>Type 2 diabetes (T2D) is a significant risk factor for adverse outcomes in coronary heart disease (CHD). We investigated whether inflammation and immune dysregulation, measured using soluble urokinase plasminogen activator receptor (suPAR) and high-sensitivity C-reactive protein (hs-CRP) levels, mediate this risk.<h4>Research design and methods</h4>Patients with and without CHD enrolled in the Emory Cardiovascular Biobank had suPAR (ViroGates, Denmark) and hs-CRP levels measured and were followed for 1) cardiovascular death, 2) a composite of incident myocardial infarction and cardiovascular death, and 3) all-cause death. Fine and Gray or Cox proportional hazards models adjusted for demographic, clinical, and treatment variables were used. Regression-based causal mediatio2026-01-01T00:00:00Z2026 Mar2026-07-16T18:34:02.445Z2026-07-11T03:08:33.4ZS-EPMC129259934153333510.2337/dc25-0940